Contact Us
Chengguan District, Lanzhou, Gansu, China
© 2025 Jeifer Pharmaceutical, All Right
Reserved.
People have looked for ways to strengthen health since the days of scurvy on long ocean journeys. Vitamin C entered the scene thanks to early chemists isolating ascorbic acid in the 1930s, but its sour taste and acidity caused issues in tablets and foods. The pharmaceutical world started combining ascorbic acid with mineral salts in an effort to create gentler, stable compounds. Calcium ascorbate came out through practical need—patients needed vitamin C with less bite and more benefits. European and US pharmacopeias later standardized it, recognizing how this salt solved problems in formulation. Pharma grade standards such as BP, EP, and USP came about not in a vacuum but as a response to rising global commerce, stricter oversight, and a growing understanding that molecules behave differently depending on how you make and control them.
Calcium ascorbate stands as a buffered form of vitamin C that many in the pharmaceutical, food, and supplement industries reach for. Instead of irritating stomachs like straight ascorbic acid, it allows for higher doses with less acidic fallout. White or slightly yellow in color, it doesn’t bring pharmaceutical morality tales—just real, measured, gentle vitamin C delivery. Tablets using this form often appeal to sensitive customers. The presence of calcium adds a small but real nutritional bonus, making it a familiar face in multi-ingredient blends, powders, and drink mixes. I remember the first vitamin C powder I mixed in a glass as a kid that didn’t pucker my lips; I later learned it was calcium ascorbate at work.
This compound holds up well in the real world. As a white to pale-yellow crystalline powder, it dissolves quickly in water, bringing the solubility needed when formulating liquids, effervescents, or chewable tablets. Molecularly, you’re looking at a calcium ion paired with two ascorbate anions. It resists oxidation much better than ascorbic acid alone, which extends the shelf life of finished goods. Melting points don’t mean much for direct use, but the value comes out when formulating for heat-sensitive applications. Odorless and with a mild, neutral flavor, calcium ascorbate skips the sharp citrus blast, making it a solid pick where taste matters.
Manufacturers meet a lot of requirements before a batch qualifies as BP, EP, or USP grade. Typical specs demand over 97% purity, low heavy metal content, and precise moisture levels. Tech sheets list melting range, bulk density, and particle size distribution since these affect tableting and mixing. Any reliable lot should carry batch numbers, country of origin, shelf-life, and storage guidelines. Product labels normally reflect the ascorbic acid and calcium content, not just the salt. End-users can grasp what they’re consuming, with regulatory codes tying each lot to full documentation trails. This transparency matters not only for the law but also for customer trust. I spent years poring over certificates and spec sheets because people deserve to know exactly what ends up in their supplements and medicines.
Making calcium ascorbate typically involves neutralizing pharmaceutical-grade ascorbic acid with calcium carbonate or calcium hydroxide in water under controlled conditions. This reaction produces calcium ascorbate and carbon dioxide—a straightforward approach that avoids harsh solvents and keeps impurities low. Manufacturers focus on thorough drying and milling to maintain uniform texture and avoid clumps. Keeping oxygen exposure to a minimum during production remains a must; even mild oxidation can sap vitamin C content before the product hits shelves. The process, once dialed in for consistency, delivers lots that pass tight pharmacopeial checks, a lesson I learned in factory settings where every failed batch wastes time and trust.
As a salt of ascorbic acid, calcium ascorbate resists breakdown in the presence of air and light better than straight vitamin C, but it still breaks down with heat, alkaline pH, or extended exposure to metal ions. Many researchers and formulators modify it further by granulating it with flow agents or blending it with protective coatings to guard against environmental stress. This salt also undergoes ion exchange reactions in the gut, splitting into bioavailable ascorbate and free calcium. Using it alongside other mineral ascorbates can tailor dose profiles, something manufacturers learned after early blends tasted off or lost potency during storage.
Different names float around for calcium ascorbate, depending on regulatory history, region, and branding. Some call it Ascorbic acid calcium salt; others label it E302 or refer to it as Buffered vitamin C. Trade names like Ester-C, although often including additional metabolites, sometimes overlap in popular lingo. Recognizing these synonyms brings clarity to confusing ingredient lists, important for practitioners and customers navigating crowded supplement shelves. I’ve seen confusion stretch across languages and continents, so clarity in labeling carries real value for anyone in research, development, or sales.
Handling calcium ascorbate in the factory or pharmacy setting doesn’t demand elaborate protocols, but strict hygiene and dust control play a role in safe operation. Workers need gloves, masks, and good ventilation, especially during large-batch mixing and packaging. Regulatory agencies set exposure limits primarily to limit chronic inhalation of fine powder. Regular audits, validated cleaning, and lot tracing keep cross-contamination at bay, especially since vitamin C products often run alongside allergens or other active ingredients. I’ve witnessed the impacts of small mistakes—crossed lines leading to recalls or quarantined batches—emphasizing that standards aren’t just about compliance but about protecting health and brand reputation.
Calcium ascorbate found fans in pharmaceuticals, supplements, food fortification, and even cosmetics. It stabilizes vitamin C fortification in infant formulas or energy drinks and fits gentle, high-dose tablets for those prone to gastric sensitivity. Food technologists use it to keep fresh colors in fruit snacks and beverages. Animal nutrition specialists value its resilience to heat in pelleted feeds. Cosmetically, mildness and stability make it suitable for creams and serums aimed at brightening or protecting skin. Its wide use reflects trust built over years of testing and real-world experience—customers return to brands that deliver gentle, stable results.
Research teams continue exploring calcium ascorbate’s bioavailability in comparison to other vitamin C forms, investigating synergies with magnesium or zinc ascorbates. There’s a focus on how it fares in new formulations, from sustained-release tablets to ready-mix beverages where pH and oxidation pose unique challenges. Scientists track its absorption rates, tissue retention, and oxidative resistance, seeking that elusive edge in supplement efficacy. University and industry researchers regularly present new data at nutrition science conferences, reflecting the world’s ongoing commitment to finding ways to deliver crucial nutrients safely and efficiently.
Toxicology research gives calcium ascorbate strong marks for safety, with high-dose studies in both humans and animals showing extremely low risk. The rare side effects—sometimes mild diarrhea at mega-doses—reflect vitamin C’s well-known limits for oral intake rather than anything unique to the calcium salt itself. Studies confirm that calcium loads from supplementation remain modest, avoiding the risks that come from excessive calcium carbonate or other minerals. Researchers still monitor possible kidney stone risks in predisposed populations, but broader reviews show routine use aligns with a long record of safety in pharmaceuticals and food products.
The horizon holds fresh opportunities for calcium ascorbate as demand for clean-label, mild, and multi-functional nutrients increases. Nutritional personalization trends fuel interest in custom-blended vitamin C complexes, where mineral ascorbates play a starring role. Advances in process control and particle engineering could yield forms with even better taste, mixability, or stability under challenging conditions. As anti-aging and immune-support markets expand, researchers keep testing how buffered vitamin C salts perform in combination with probiotics or polyphenols. The drive for sustainable sourcing and lower-carbon manufacturing may shape future calcium ascorbate products as supply chains respond to climate and environmental pressures.
Ask anyone who’s worked in a supplement company or even spent time in a food lab, and they’ll tell you, vitamin C is easy to formulate but tough to keep stable. Ordinary ascorbic acid likes to cause problems in tablets and powders, especially where pH or shelf life makes a difference. Calcium ascorbate steps in and helps, blending that much-needed antioxidant kick of vitamin C with a dose of calcium in a single ingredient. With BP, EP, and USP grades, the stuff meets tight quality expectations, which makes it reliable for critical pharma uses.
Pharmaceutical companies need vitamin C not just for basic supplements. Vitamin C backs up medicines that support immune health, wound healing, and even skin-repairing creams. I’ve seen doctors reach for vitamin C infusions in hospitals when patients need a real metabolic boost. Calcium ascorbate shines as it brings less stomach irritation than standard ascorbic acid, making higher dosing easier for folks with sensitive stomachs or ulcers. Its BP, EP, and USP marks show that this isn’t some off-the-shelf food additive; it’s a substance checked from origin to shelf for purity, heavy metals, and pathogens. Doctors and patients can count on what they’re getting.
Each time you see vitamin C on a food label—especially in fortified juices, baby foods, or chewables—a form of calcium ascorbate probably sits in the background. Food technologists like it not only for vitamin C content but for its role as an antioxidant that helps keep colors fresh and flavors stable. It can help bread keep its color and stop fruit mix from turning brown too fast. In the supplement world, combining calcium and vitamin C in one shot appeals to people who want to simplify their daily pill count. There’s also a friendlier taste and mouthfeel compared to the sharp acid tang regular ascorbic acid brings. That’s more important than you’d think, especially for chewable kids’ supplements or tooth-friendly tablets.
All those Pharma grades—BP, EP, USP—they tell companies and patients that a product went through rigorous tests. Supply chain managers can drop it into product development without worrying about recalls or regulatory snags. People working in manufacturing know recalls don’t just cause profit loss; they damage trust. Sourcing ingredients that meet every box builds trust with regulators and with patients who actually swallow the end product.
Every ingredient has trade-offs. Combining vitamin C and calcium brings double benefits, but for patients with kidney stones or calcium restriction, it’s a no-go. Manufacturers must check labels, screen patient history, and educate both pharmacists and consumers. Transparency builds reliability, especially with detailed Certificates of Analysis. Smaller companies sometimes skip this, but consumer advocacy over the years shows the demand for full disclosure. It’s not just enough to pass a test; it’s about sharing those results openly.
People inside the supplement and pharma industries keep pushing for better delivery methods. Calcium ascorbate already helps reduce irritation and improve taste—two keys for compliance in older adults and kids. As research continues, maybe we’ll see new blends or novel delivery platforms. The core idea—making sure the basic vitamins people rely on are both pure and pleasant—won’t shift. As long as people care about getting reliable nutrition, ingredients like calcium ascorbate BP EP USP grade will keep getting a seat at the manufacturing table.
Calcium ascorbate has quietly become a favorite in nutrition and pharmaceuticals for delivering both vitamin C and calcium in a single dose. For people who can’t stomach the acidity of straight ascorbic acid, calcium ascorbate feels gentler. In the factory, behind each lot, there’s a sharp focus on getting everything just right. That’s where British Pharmacopoeia (BP), European Pharmacopoeia (EP), and United States Pharmacopeia (USP) grades step in.
Pharma grade calcium ascorbate keeps benchmarks high. Purity tells the real story. Specifications for BP, EP, and USP versions look quite similar. These standards want calcium ascorbate that’s at least 99.0% pure after drying. Water sits around 0.1% to 0.25%, with just enough moisture to hold the molecule together, but not enough for growing microbes. Testing chases down possible contamination from heavy metals—limits drop below 10 parts per million. No one likes surprises from lead, arsenic, or mercury. Residue on ignition sits well below 0.1%, making sure there’s no left-behind junk from the process.
You won’t find visible impurities in the powder. A clean, nearly white or pale yellow powder is what everyone expects. In my time touring supplement facilities, I’ve seen how strict these standards run. One off-color batch doesn’t ship. This protects patients who trust what’s inside a capsule. BP, EP, and USP want the pH to stay close to neutral—ideal for the body and for blending into finished tablets and powders.
A lot of this can sound like chemistry lab work, but one thing sticks out: any deviation opens the door to real health risks. In university, I learned about vitamins from textbooks, but I saw things get serious in a research lab, where even a tenth of a percent off meant scrapped batches. People taking calcium ascorbate aren’t always in robust health—children, pregnant mothers, and immune-compromised patients might use it. Industry watchdogs seek purity because patient safety rides on every shipment.
Routine lab checks chase after contaminants and breakdown byproducts. Fast, reliable chromatography tracks trace amounts of ascorbic acid and calcium that fall outside the main molecule. Each grade—BP, EP, USP—leans on strict methods that include titrations and standard solutions. Since many supplements cross borders, facilities often seek all three grades in certification. Some global pharma companies look to third-party audits for extra assurance, knowing poorly controlled raw material can ruin a batch at final inspection.
Reading specifications and purity levels only gets you part of the way. Real safeguards turn up in process controls, audits, and a culture of double-checking. Some facilities turn to automated systems that flag out-of-spec batches fast, reducing human error. Elevating worker training has proven as critical as fancy machines. Quality isn’t just a certificate on the wall; in practice, it reflects hard work across the chain, from supply to finished capsule. With growing interest in clean-label vitamins and supplements, keeping these standards high won’t just win regulatory approval. It builds trust, batch by batch.
Calcium ascorbate, a buffered form of vitamin C, brings together the antioxidant effects of ascorbic acid and the calcium your body already relies on for bone and nerve function. Plenty of people have trouble tolerating the acidity of straight vitamin C, and this ingredient gives them another option. It's familiar on ingredient lists for chewable tablets, supplements, and even some snack bars, where it promises both the perks of vitamin C and a gentler experience for the stomach.
The BP, EP, and USP standards aren’t just letters stamped on a bag. These are signals for strict quality control, and real-world safety. Manufacturers in both pharma and food industries use these grades to prove their calcium ascorbate holds up to guidelines for purity, identification, and allowable traces of impurities. The standards make it easier to trust the source. I’ve had my own doubts over ingredient quality in generic vitamins, and a pharma-grade certification does help settle nerves. The pharma world, in my experience, won’t accept anything less.
Mixing compounds like calcium ascorbate into medicines or snacks calls for more than a clean factory. Pharmaceutical-grade means missing heavy metals, keeping microbe counts in check, and offering a known profile for things like pH and solubility. I’ve seen how a sloppy supplier creates headaches across the business. Inconsistent powder grades can mess with dosing, flavor, and stability. For anyone tasked with food or supplement development, using pharma-grade material offers peace of mind and helps keep recalls off the radar.
Food safety agencies do not compromise on these standards. In the European Union, anything labeled with an ‘EP’ badge has cleared some of the toughest hurdles. Many pharmaceutical contracts won’t even get off the ground unless suppliers can show BP, EP, or USP documentation. This is not bureaucracy for its own sake. Contamination, adulteration, or a poorly understood ingredient can wreck both trust and health. In one case that stuck with me, a nutraceutical project pivoted to calcium ascorbate after customers complained of stomach upsets from pure ascorbic acid. Pharma grade was the only option our quality team would sign off on.
Pharma grade calcium ascorbate delivers on stability. There’s less chance of unexpected changes during storage, and the calcium component adds extra appeal for products marketed toward bone support. The ingredient’s stability is critical for pharmaceutical formulas, especially for solutions or chewables shelfed for months. In the food sector, producers look for an ingredient that resists spoilage and works smoothly with other nutrients. A product team once explained to me that lower grades of vitamin C kept wrecking the taste and appearance of their powdered blends. The right grade cut down customer complaints and opened up more export options.
Cost climbs with pharmaceutical-grade ingredients. Buying this grade of calcium ascorbate means a budget hit, especially for small startups. That’s the trade-off: budget versus certainty. Some companies try to blend lower purity grades to save money. In the long run, cutting corners means risks, including recalls or lost certification. One solution is to source directly from certified manufacturers in larger quantities, which often brings costs down. A robust supplier audit program and batch testing help sidestep problems before they land in the consumer’s hands.
Pharmaceutical-grade calcium ascorbate checks the boxes for both medicine and fortified foods. Real-world experience and regulatory requirements support its place in these sectors. Buying quality from the beginning means fewer worries and a safer end product. Committing to trusted suppliers is an investment with payback you can count on.
Calcium Ascorbate doesn’t get the spotlight vitamin C does, though in the pharmaceutical world, this compound pulls a lot of weight. Its value comes from a combination of stability and gentleness—both in medicines and supplements. The science behind storage isn’t just a chemistry textbook requirement; it’s about protecting both product strength and the people taking it.
A stash of Calcium Ascorbate left near a sunny window or in a damp warehouse loses its snap faster than most imagine. Moisture clings, heat stirs reactions, and before long, what starts as a clean, white powder becomes clumpy, yellow-tinged, and weaker. Pharmacopeias suggest keeping it below 25°C in a dry spot, but guidelines alone won’t shield it from real-world mishaps.
From my own experience in a hospital dispensary, products sitting too close to radiators arrived with torn seals and musty notes—clear signs things had gone sideways. Once, a whole batch had to be set aside. Not because anyone ignored rules, but because simple, everyday things like a leaking pipe undermined storage conditions. This costs time, money, and erodes trust.
It’s tempting to treat calcium ascorbate like table salt, getting loose with storage in the name of convenience, but this doesn’t just impact shelf life—there’s a ripple effect on product potency and safety. Exposure to air draws in water vapor, and with each cycle of wet-dry, there’s a risk of breakdown. People depending on precisely-formulated doses don’t get the benefit they expect.
Storing Calcium Ascorbate in its original, tightly sealed packaging isn’t just box-ticking. Pharmacies, manufacturers, and even community clinics need to resist transferring bulk powder into open jars or plastic tubs. Good containers aren’t just airtight—they block light, which helps keep oxidation at bay.
Every storage area benefits from low humidity. Investing in decent dehumidifiers in locations prone to dampness makes a difference you can feel in the air and see in your stock’s condition. Some of the best setups I’ve seen use climate monitors—simple digital readouts that tell staff at a glance whether temperature and humidity levels are out of range.
Training for folks handling storage isn’t a one-off exercise. Workers rotate, new team members join, and habits slip. Ongoing, practical instruction beats a raft of posters. Team leaders need to run spot checks and shift conversations about storage out of the “back office” and into day-to-day awareness.
It pays to keep written logs of storage conditions, and to actually look at these logs, not just stack them in a binder. Patterns emerge—like rising humidity after rain—which help predict future issues before product loss sneaks up.
World Health Organization guidance says that many vitamins, including ascorbate salts, stay most stable in temperatures below 25°C with humidity under 60%. Real-world results back this up: material stored under these conditions rarely shows decline until long after official expiry.
Storing Calcium Ascorbate the right way isn’t burdensome. It’s the difference between delivering true pharmaceutical quality and rolling the dice. For those of us counting on supplements and medications, that peace of mind matters.
Supplements come with labels, certifications, and plenty of confusion. “Pharma Grade” gives off a sense of security, but purity often means more than just the absence of contaminants. People checking labels want to know: Will this trigger an allergy? Is this from genetically modified sources? These questions get louder when the supplement goes into medicine or food.
Most of my friends with food allergies have a habit of triple-checking every supplement. A common question pops up: “Is there hidden dairy, soy, or wheat?” Calcium ascorbate, made from ascorbic acid and calcium, often claims to be allergy-free. If manufactured using good pharmaceutical practices specified by BP, EP, or USP standards, it shouldn’t contain milk, gluten, peanuts, or soy. Still, real life shows gaps. Equipment or supply chains sometimes touch common allergens. Proper documentation should state exactly what other substances touch the product. The FDA’s Current Good Manufacturing Practice (CGMP) regulations require companies to prevent cross-contact and clean equipment—but mistakes or mislabeling slip through at times.
Seeing “allergen-free” on a product does most of the work for peace of mind, but not all manufacturers fully document every risk. The safer bet is asking for a full Certificate of Analysis or an allergen statement that lists risk points. Some companies go as far as third-party allergen testing, which increases trust but also raises costs.
GMO-free status matters for a lot of people, especially in places with strict labeling like the EU. Vitamin C (ascorbic acid) usually starts as glucose, and most industrial-scale sources use maize or corn. In North America, most corn is genetically modified. If a company claims GMO-free on their pharmaceutical grade, they either use non-GM sources or process it so much that no traces remain. Some suppliers in Europe use beet sugar or certified non-GMO corn.
People who need reassurance should demand full ingredient traceability. EU regulations, for example, do not allow GMO contamination above a certain threshold without clear labeling. Industry watchdogs and consumer protection groups sometimes run independent tests and publish reports, especially when they catch brands falsely using the GMO-free label. Genuine, pharma-grade certifications like USP and EP focus on purity and identity, but they don’t always guarantee non-GMO origins—unless specified in supplier documentation.
Standing in the pharmacy aisle isn’t just about price. It’s about believing what’s on the label. Pharma suppliers aiming for real trust give customers paperwork that’s clear, not just full of jargon. Allergen-free status comes from strict cleaning, good traceability, and honest labeling. Non-GMO claims need more than a sticker; they need proof at every point in production.
Manufacturers can bring more trust to the table by opening up about their supply chain and inviting audits. More companies are joining voluntary programs from organizations like the Non-GMO Project or getting independent allergen certifications. These steps matter to people with allergies or strong opinions about genetic modification. If producers genuinely clean up their processes and document it, consumers win.
Asking questions keeps companies honest. As long as people stay curious and push for better answers, labels will meet higher standards—so those with allergies, dietary restrictions, or concerns about GMOs see fewer surprises and more reasons to trust the pills and powders on their shelf.
| Names | |
| Preferred IUPAC name | Calcium di[(2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-yl]propanedioate |
| Other names |
Calcium Salt of Ascorbic Acid Calcium L-ascorbat E 302 Calcium Ascorbate Dihydrate Calcium Ascorbate Vitamin C Ca(C6H7O6)2 |
| Pronunciation | /ˈkæl.si.əm əˈskɔːr.beɪt/ |
| Identifiers | |
| CAS Number | 5743-28-2 |
| Beilstein Reference | 1721759 |
| ChEBI | CHEBI:31347 |
| ChEMBL | CHEMBL1201533 |
| ChemSpider | 74359 |
| DrugBank | DB00126 |
| ECHA InfoCard | 03cdf35e-a03d-4f1b-93a7-17b47779f6be |
| EC Number | EC 222-093-9 |
| Gmelin Reference | 83354 |
| KEGG | C00443 |
| MeSH | D015805 |
| PubChem CID | 5684 |
| RTECS number | AFO3220000 |
| UNII | JKM97X7B81 |
| UN number | UN3243 |
| CompTox Dashboard (EPA) | CompTox Dashboard (EPA) of product 'Calcium Ascorbate BP EP USP Pharma Grade' is **DTXSID3078818** |
| Properties | |
| Chemical formula | C12H14CaO12 |
| Molar mass | 678.43 g/mol |
| Appearance | White or almost white, crystalline powder |
| Odor | Odorless |
| Density | 0.95 g/cm³ |
| Solubility in water | Freely soluble in water |
| log P | -5.1 |
| Acidity (pKa) | 6.2 |
| Basicity (pKb) | 8.2 |
| Magnetic susceptibility (χ) | Diamagnetic |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 309 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -1606 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -1581 kJ/mol |
| Pharmacology | |
| ATC code | A11GA |
| Hazards | |
| Main hazards | May cause eye, skin, and respiratory irritation |
| GHS labelling | GHS07, GHS hazard statements: H315, H319, H335 |
| Pictograms | GHS07, GHS08 |
| Signal word | Warning |
| Hazard statements | H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation. |
| Precautionary statements | Keep container tightly closed. Store in a cool, dry place. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling. Use with adequate ventilation. |
| NFPA 704 (fire diamond) | 1-0-0 |
| Lethal dose or concentration | LD50 (Rat, Oral): >5000 mg/kg |
| LD50 (median dose) | LD50 (oral, rat): >5000 mg/kg |
| NIOSH | Not listed |
| PEL (Permissible) | Not established |
| REL (Recommended) | Recommended Exposure Limit (REL): 10 mg/m³ (total dust) as 8-hour TWA. |
| IDLH (Immediate danger) | Not Listed |
| Related compounds | |
| Related compounds |
Sodium Ascorbate Ascorbic Acid Magnesium Ascorbate Potassium Ascorbate Calcium Gluconate Calcium Chloride |
Chengguan District, Lanzhou, Gansu, China
