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Sodium Ascorbate BP EP USP Pharma Grade: A Comprehensive Exploration

Historical Development

Ascorbic acid, the foundation of sodium ascorbate, caught the attention of scientists well over a century ago. Scurvy drove the earliest studies, reminding us that vitamin C is not just a simple supplement but a lifesaver. Debates on stability and solubility kept researchers busy through the 1900s. When pharmaceutical labs needed reliable options for vitamin C inclusion in sensitive medicines, sodium ascorbate emerged. Early on, the industry struggled with ascorbic acid’s acidity, not just for patient comfort but for ingredient resilience. Eventually, sodium ascorbate bridges the gap, offering a less acidic alternative while preserving all antioxidant functions we associate with vitamin C. Major pharmacopoeias—British (BP), European (EP), and United States (USP)—now demand strict consistency, underpinning this substance’s credibility in both therapy and product design worldwide.

Product Overview

Sodium ascorbate, with the chemical formula C6H7NaO6, crystallizes the partnership between vitamin C and sodium. It’s a white to pale yellow powder, almost odorless, with a mild salty-sour taste; the flavor tastes less biting than straight ascorbic acid, which explains its popularity for oral supplements and injectables. Manufacturers ship it in airtight drums for big operators, or smaller pouches for compounding pharmacies. This compound slots easily into pills, tablets, and even eye drops, taking advantage of its broad range. Marketers sometimes call it a buffered vitamin C, which is technically accurate—its pH gives gentle options for those with a sensitive stomach. Any pharmacist can spot the difference in their stock room from a glance at the powder’s fine, almost smooth texture.

Physical & Chemical Properties

Powdered sodium ascorbate dissolves in water rapidly, with typical solutions having a pH between 7.0 and 8.0. That pH neutralizes acidity, making the mixture easier on mucous membranes. The melting point floats around 220°C with decomposition. Unlike some ascorbates, this salt avoids clumping in damp air due to the loose, granular consistency. Chemically, sodium ascorbate serves up the same antioxidant action as ascorbic acid—donating electrons to neutralize reactive oxygen species. It isn’t hydrophobic, so it won’t float like some other supplement powders; every batch that passes QC testing should measure up to high standards for purity (over 99%). Sodium ascorbate doesn’t last forever, though: keep it dry and cool if you want shelf life north of two years.

Technical Specifications & Labeling

Pharma-grade sodium ascorbate must fit pharmacopeial definitions for sodium content, assay (usually 99.0% to 100.5%), and max allowable levels of impurities, such as heavy metals and microbiota. BP, EP, and USP all demand strict tracing, batch numbers, and country-of-origin details on every label. Product datasheets bullet out the particle size (often between 200 and 500 microns), solubility, and precise pH, plus reminders like “store away from moisture.” Shipping containers feature tamperproof seals, and every kilo produced lines up with batch-specific certificates of analysis. This transparency stands as a core promise in any pharma deal—patient safety and quality come first, way ahead of marketing blurbs or packaging gloss.

Preparation Method

Production cycles for sodium ascorbate start with fermentation—usually using glucose as a substrate. Fermentation gives pure ascorbic acid, after which sodium bicarbonate or sodium carbonate reacts in solution, converting the acid to its sodium salt. Nearly every manufacturer I’ve spoken with relies on high-precision mixing, avoiding temperature spikes that degrade vitamin C’s molecular structure. Once the reaction finishes, filtration and spray drying or vacuum drying create the bulk powder, which then passes through sieving to tune the particle size. No synthesis step feels complete without exhaustive impurity checks; high-performance liquid chromatography remains the gold standard. Running these giant reactors inside stainless-steel vessels, workers constantly watch pH and sodium ratios. Some companies claim green processing with lower waste streams, which matters more in a world watching each gram of solvent and each cubic meter of water use.

Chemical Reactions & Modifications

Sodium ascorbate resists many breakdown pathways, but oxidizing agents, heat, and high humidity can trigger slow loss of potency. When exposed to oxygen, the ascorbate oxidizes to dehydroascorbic acid, which offers limited bioavailability for most mammals. Sometimes, scientists design derivatives by linking ascorbate with lipids or polymers for sustained release; in cosmetic science, sodium ascorbyl phosphate emerges from this type of chemical tinkering. Sodium ascorbate itself plays the electron donor in redox titrations for quality control, underlining time after time just how central its chemistry is to the integrity of finished pharmaceuticals. If I had to pick, the best feature of sodium ascorbate is its stability in solution compared to ascorbic acid alone. This means longer shelf life in reconstituted medicines, whether in home care or a hospital setting.

Synonyms & Product Names

Supply chains refer to sodium ascorbate by many names, which can cause confusion. You’ll see terms like Monosodium ascorbate, Vitamin C sodium salt, E301 (in food applications), and Ascorbic acid sodium salt. On pharmacy shelves, brands market sodium ascorbate as “Buffered Vitamin C Powder” or “Gentle C,” trademarks depending on jurisdiction. Scientific research prefers the unambiguous C6H7NaO6 or CAS Number 134-03-2, to skip the semantics entirely. If you dig through online ingredients in processed foods or intravenous fluids, you’ll find these synonyms attached, always tracing back to the same basic chemistry. Patients rarely see a difference; it’s back-end operators and formulators who argue over granular naming.

Safety & Operational Standards

Daily safety for sodium ascorbate production rests on fundamentals: personal protective gear, fitted respirators, rigorous cleaning standards, and running HEPA filtration in production suites. Operators verify facilities against ISO 9001 and GMP specifications, which means batch-specific logs, recall protocols, and industry compliance audits—no exceptions. Handling instructions warn against long exposure to skin and eyes, despite sodium ascorbate’s relatively mild irritation risk. It matters to note that sodium ascorbate’s sodium load calls for clear dose calculations in hospitals, especially for patients with renal concerns or hypertension. Routinely, regulators double-check for contamination from lead or arsenic, and most suppliers publish full toxicology reports to calm any doubts in purchasing departments. Employees run annual re-training on spill control, disposal, and adverse event reporting; too many stories get out about the early days of chemical handling where a little ignorance led to big mistakes with dust inhalation or improper waste dumping.

Application Area

I’ve seen sodium ascorbate everywhere—if you read ingredient panels, it’s a regular in injectable solutions, fortified foods and beverages, nutritional supplements, and antioxidant boosters for animal feed. In hospitals, doctors prefer it to ascorbic acid for patients with sensitive gastrointestinal tracts or those receiving parenteral nutrition. The sodium form’s balanced pH gives IV solutions better tolerance and less burning at the injection site. Processors in food manufacturing rely on sodium ascorbate as an antidote to nitrite preservatives, stopping the formation of nitrosamines, a class of carcinogens. Veterinary medicine leans heavily on it, especially in large-scale livestock health management. Even skincare brands use sodium ascorbate in brightening serums, where stability and water solubility mean the difference between an effective product and one that oxidizes before it makes it past the shipping depot.

Research & Development

Scientists often single out sodium ascorbate when they design experiments in cell culture and nutritional biochemistry. Researchers choose this salt for its predictable pH and improved solubility, making assay conditions easier to control. Recent projects in regenerative medicine probe sodium ascorbate’s impact on collagen synthesis and wound healing, chasing the benefits of faster tissue repair. Pharmaceutical engineers keep experimenting with sodium ascorbate as an adjunct to antibiotics, hoping its antioxident chemistry helps blunt oxidative stress during infections. With climate change confronting raw material supply chains, I expect more R&D teams will look for alternative fermentation feedstocks and green process tech. Huge grants are fueling studies into sodium ascorbate’s protective role in neurodegenerative diseases, thanks in part to its track record for crossing into sensitive cellular areas without much inflammation.

Toxicity Research

Toxicologists spent years examining sodium ascorbate’s safety; the consensus holds it up as remarkably low-risk, provided dosing stays within recommended limits. Acute oral and intravenous toxicity numbers sit comfortably above most real-world consumption patterns. Adverse effects rarely show up unless a patient takes very high doses—then the sodium can raise blood pressure or bring mild osmotic diarrhea. Chronic exposure studies on rodents did not flag significant mutagenic or carcinogenic outcomes, a relief for drug developers. Despite the clean record, regulators still flag the risk for sodium overload, which in cardiac patients or those with chronic kidney disease may prove problematic. In practice, health agencies focus mostly on cumulative sodium intake, not so much the ascorbate molecule itself; still, companies must show robust animal and human data before new indications hit the health market. Increased vigilance and clear communication on sodium content help avoid adverse outcomes, especially as broader groups of people turn to vitamin supplements for prevention or therapy.

Future Prospects

Demand only appears to be growing, fuelled by a consumer push for wellness and preventive medicine. Pharmaceutical engineers know that biosimilar and biologic therapies involve complex formulation challenges, and the gentle chemistry of sodium ascorbate looks increasingly relevant. Its future includes more sophisticated delivery systems, like nanoformulations that shepherd the vitamin into immune cells selectively. Clean-label trends—driven by ingredient transparency—favor sodium ascorbate, which carries a straightforward safety profile. If regulators push for lower sodium content in fortified foods, the next leap might involve hybrid molecules or mineral blends. Implementation of blockchain in supply-chain logistics is also strengthening product traceability, giving peace of mind in industries haunted by counterfeit ingredients. Innovators will likely develop more sustainable fermentation platforms to reduce energy consumption and waste generation in bulk vitamin C production. As populations age and diet-related diseases spread, both clinical and preventative uses for sodium ascorbate look set to keep expanding, riding a wave of research committed to both health benefits and responsible production.




What is Sodium Ascorbate BP EP USP Pharma Grade used for?

Understanding the Role in Health and Medicine

Walk into any pharmacy or glance at the label on a vitamin supplement, and it won’t take long to spot sodium ascorbate. This compound does a lot more than fill a spot on an ingredients list. It’s a form of vitamin C that people, especially those with sensitive stomachs, can tolerate better than ascorbic acid. In my experience, anyone tackling vitamin C deficiencies or working with intravenous therapies in a hospital setting likely knows sodium ascorbate by name.

Why Demand for Quality Matters

Pharma grade material—marked as BP, EP, or USP—means the product meets strict standards. These standards, set by recognized pharmacopeias, protect people. Once, I watched a pharmacist reject a shipment because it missed these marks by a hair, knowing full well that even the smallest contaminant could cause an allergic reaction or compromise a patient’s health. The pharma grade label matters because people trust they’re taking something pure, safe, and effective.

It’s Not Just for Pills

Sodium ascorbate works in chewables, effervescent tablets, syrups, and even intravenous solutions. Try swallowing a harsh, acidic vitamin C tablet if you have a sensitive stomach. Sodium ascorbate changes everything. It’s gentler and gets absorbed without causing the same irritation. Hospitals use it in IV form to tackle serious viral infections or severe deficiencies, particularly in critical care. This grade becomes essential for ensuring a clean and consistent product—no room for shortcuts when a life hangs in the balance.

Stability and Shelf Life

Regular vitamin C, left exposed to air and moisture, loses its strength fast. Sodium ascorbate stands up better to these conditions. For packaged medicines and supplements that might travel thousands of miles, this stability keeps the product potent until it reaches the person who needs it. Manufacturers bank on this attribute to design gummies and liquids that parents can trust for their kids.

Safety and Bioavailability

Some people need to monitor their sodium intake. The amount added by sodium ascorbate in moderate doses doesn’t typically cause trouble. Doctors check for hidden sodium in diets, especially among people with heart or kidney issues. For the general public, sodium ascorbate can deliver a strong punch of vitamin C without causing stomach trouble.

Pushing for Better Manufacturing and Transparency

It’s easy to forget that the grade stamped on the label comes after long hours spent in testing labs and through quality audits. I remember seeing reports of contamination scares in the supplement industry; it shook people’s confidence. To strengthen trust, companies need batch-specific certificates, transparent sourcing, and clear communication on how products are made and tested. No one wants to gamble with their health, and reputable suppliers know this.

Toward Accessible and Affordable Vitamin C

Chasing an optimal diet doesn’t always work in the real world, especially with today’s prices. Pharma grade sodium ascorbate gives doctors, nutritionists, and average folks a solid tool to bridge nutrition gaps. As long as producers put safety and transparency ahead of profits, this ingredient will stay indispensable in everyday pharmacy and clinical care.

How is Sodium Ascorbate BP EP USP Pharma Grade different from regular Vitamin C?

Understanding What’s In Your Supplements

Most people look at vitamin C as something you grab off the shelf during cold season, but there’s a technical world hiding behind those orange tablets. Walk into a pharmacy or scroll through an online catalogue, and you’ll come across names like Sodium Ascorbate BP EP USP Pharma Grade. That mouthful might sound like a science experiment, but it stands for a vitamin C form with a strict pedigree—and crucial differences from the regular ascorbic acid found in most everyday supplements.

Real Differences Go Beyond the Label

Vitamin C usually means ascorbic acid. It’s the pure, acidic version most people grew up with. Too much of it, especially on an empty stomach, can lead to indigestion or downright stomach pain. Sodium ascorbate steps in as a buffered alternative. Mixed with sodium, this version helps cut down acidity. People dealing with digestive issues, or those who take larger doses for medical reasons, often find that sodium ascorbate feels much gentler.

I’ve worked with folks who manage chronic illnesses, and for some, regular ascorbic acid just isn’t an option. Their bodies protest each morning. Sodium ascorbate changes things for them. It’s still vitamin C, but more comfortable to digest.

The Meaning of "Pharma Grade" and Those Fancy Abbreviations

BP, EP, and USP stand for British Pharmacopoeia, European Pharmacopoeia, and United States Pharmacopeia. These standards mean the sodium ascorbate has survived rigorous purity and quality checks. Unlike the standard vitamin C sold in big jars, pharma grade compounds must meet minimums on purity and maximums on contamination. Manufacturers follow rules that protect patients who need life-saving treatments or those who receive injections and IV drips.

During the pandemic, these standards moved into view. Hospitals needed vitamin C for infusions, not only to supplement diets but also as part of treatments. Impurities in regular-grade vitamin C can cause serious reactions when introduced directly into the bloodstream. Pharma grade reduces that risk.

Safety Really Has a Price

Pharma grade vitamin C costs more, and that’s not just a company decision. Purity checks cost money. Equipment must stay clean. Labs have to document every step, trace every ingredient, and catch every foreign particle before it leaves the factory floor. For most people, this might seem like overkill. But for infants in clinics, cancer patients, or folks with rare allergies, even a tiny impurity can lead to big problems.

Regular vitamin C alone rarely causes trouble when chewed as a tablet or mixed into a smoothie. Those aren’t sterile environments. But as soon as a vitamin crosses from the digestive system into the blood, tolerances change and safety standards rise.

How Should People Decide Between the Two?

Not everyone needs sodium ascorbate, and not everyone needs pharmaceutical grade. People looking for basic immune system support usually won’t get extra benefits from pharma-level purity. Folks with sensitive stomachs or specific health instructions from doctors may get more from sodium ascorbate, specifically if a prescription calls for it. Pharmacies and health professionals know these distinctions, and usually recommend pharma grade for injectable use or critical care.

Everyday consumers should read labels and ask questions at the pharmacy. It pays to understand not just what ingredient goes into the bottle, but how strictly it’s controlled. For sensitive cases, those controls matter. For everyday life, regular vitamin C will often do the job just fine.

What are the specifications and purity levels of Sodium Ascorbate BP EP USP Pharma Grade?

Why Sodium Ascorbate Matters in Pharma

Sodium ascorbate isn’t just an alternative to ordinary vitamin C. This form packs a punch for people with sensitive stomachs or those who need higher doses without acidity. Working in pharmaceutical manufacturing, I’ve seen just how important it is to meet strict criteria—not just for customer trust, but for patient safety. The difference between technical grade and pharma grade comes down to the details: purity level, contaminant thresholds, and how consistently those numbers stick batch to batch.

Purity Levels: The Unforgiving Numbers

Sodium ascorbate for pharmaceutical or nutraceutical use seriously must follow the British Pharmacopoeia (BP), European Pharmacopoeia (EP), and United States Pharmacopeia (USP) standards. Pharma grade sodium ascorbate must deliver purity over 99%. Official specs usually place acceptable ascorbate content between 99.0% and 100.5%. This tight window aims to cut down on unwanted by-products or residues that might sneak in from raw materials or sloppy processing.

Impurities grab a lot of attention. For pharma grade, limits cap at tiny values for heavy metals, lead, arsenic, and oxalic acid. For example, lead can’t go higher than 2 parts per million (ppm), and heavy metals as a whole must stay under 10 ppm. Moisture content also gets checked—below 0.25% loss on drying helps prevent clumping and keeps tableting predictable. Sulphated ash, an indicator of inorganic residuals, should not exceed 0.1% by BP and similar standards.

Physical and Chemical Properties That Matter

On the production floor, the physical character of sodium ascorbate tells you a lot about how it will behave in a tablet press or capsule filler. Pharma grade powder comes as a white to pale, almost crystalline powder. It dissolves easily in water—at least 200g per liter at 20°C—so it works both for liquid and solid formulations. The pH of a 5% solution usually stays between 7.0 and 8.0, which gives it a gentle, neutral profile, perfect for sensitive patients.

Testing goes further. Each batch should test negative for abnormal odour, and the melting point must fall close to 190°C—just a bit below standard ascorbic acid, thanks to the sodium salt. Specific optical rotation, a way to check if the molecule is right-handed as nature intended, needs to land somewhere between +103° and +106°.

Quality Means Trust

Poor-quality sodium ascorbate can bring unwelcome surprises. Once, a batch from a cheap overseas supplier brought the moisture above 1%, and the finished tablets got gummy and soft. Nobody wants that in a pharma setting. Investing in pharma grade makes sense, mostly because tight quality ensures consistency and traceability. Pharmacies, hospitals, and supplement brands all rely on the purity and quality numbers because nobody can afford to gamble with contamination or mismatched specs.

What Solutions Make a Difference?

Training lab staff to spot out-of-spec sodium ascorbate is key. Suppliers should always deliver full certificates of analysis covering not just the big numbers—like ascorbate content—but stretch to the nitty-gritty: microbial load, loss on drying, heavy metals, and toxic residues. It helps to run quick, simple identity checks on each arrival, such as IR-spectroscopy or TLC plates, without waiting for more complex results.

By sticking to these practices and sourcing only pharma-verified sodium ascorbate—BP, EP, or USP qualified—manufacturers keep patients safe, meet legal obligations, and avoid the pain of costly product recalls.

Is Sodium Ascorbate BP EP USP Pharma Grade suitable for pharmaceutical and food applications?

Looking Beyond the Label

Sodium ascorbate appears on the ingredient list of both medicine bottles and breakfast juices. This form of vitamin C comes with a reputation for delivering benefits where purity and consistency really count. The BP, EP, and USP suffixes reference standards used by British, European, and American pharmacopeias. These set tight benchmarks for contaminants, potency, and physical quality. Folks in the health business lean on these codes to tell the real stuff from the untested alternatives.

Quality and Safety Go Hand in Hand

Demanding production processes make these pharmacopeia-grade versions a step above basic food ingredients. Only pharmaceutical grade sodium ascorbate clears strict tests for heavy metals, pathogens, and performance. Tablets and syrups that miss these marks bring up real worries. In my time consulting for manufacturers, we’ve seen recalls and consumer backlash from products that took shortcuts with lower-grade ingredients. It’s no secret—trust takes hits that are hard to fix once broken.

Food Applications: Not All Vitamin C Is the Same

Most folks expect food-grade additives to meet basic safety. Some sodium ascorbate finds its way into cured meat, drinks, and snacks because it keeps colors bright and flavors fresh. Yet much of the vitamin C that does this lacks the same traceability as pharma-grade material. Consistency becomes harder to judge. Sourcing sodium ascorbate stamped BP EP USP cuts the guesswork. You know metals such as lead or arsenic fall well below safety limits. There’s less wiggle room for things to go wrong in the supply chain—which matters more as global sourcing spreads ingredients far from home.

Why Pharmaceutical Grade Matters in Health Products

Supplements on pharmacy shelves often promise real benefits. That promise can fade fast if a vitamin tablet delivers less than the label claims. I’ve worked with teams who lost hard-earned brand loyalty to inconsistent ingredient quality. Using pharmaceutical grade sodium ascorbate sets a high bar, keeping vitamin C levels as advertised in every pill or powder. Health professionals take this seriously. The medicines and supplements that use pharma-grade vitamin C meet regulations and public health standards, avoiding embarrassing gaps if the manufacturer faces an audit.

Risk Isn’t Just About Contaminants

It’s easy to think the only challenge is what shouldn’t be in sodium ascorbate—heavy metals, pesticides, or microbes. But if a child’s chewable vitamin doesn’t dissolve or absorb as expected, its benefits fall short no matter how clean the initial material looked. Pharma-grade quality often addresses these technical details. It’s not only health-conscious buyers who care. People running food businesses also recognize the long-term value in sticking with reliable, test-proven sources. The upfront cost pays back in fewer recalls, less hassle from regulators, and fewer angry calls from customers.

A Path Forward: Raising Standards in Food Too

Plenty of food brands already pay closer attention, especially as consumers demand cleaner labels and transparency. The tighter the standards, the less likely contaminated batches or variable performance creep in. There’s room for regulators to make BP EP USP quality a norm in more categories. From experience, the hardest part is convincing cost-focused decision-makers to stop considering only the price per kilo. Greater transparency about sourcing and regular third-party audits go a long way to building trust that lasts. Quality doesn’t happen by accident. It’s the result of daily choices backed by clear, published standards.

What are the packaging options and shelf life of Sodium Ascorbate BP EP USP Pharma Grade?

Packaging Choices Matter for Sodium Ascorbate

Sodium ascorbate, a popular vitamin C derivative, needs solid protection from air and moisture. Without it, quality drops fast and nobody wants spoiled raw material in a pharmaceutical line. I’ve seen suppliers offer it in tight-sealed drums, fiberboard barrels, airtight pails, and small multi-layer bags. In most pharma settings, 25-kilogram fiber drums with inner polyethylene liners often show up, keeping the contents dry and away from sunlight. This type of setup also gives buyers confidence about what’s inside, as tamper-proof seals cut down the risk of contamination.

Individual companies sometimes request double-layered bags inside carton boxes, wanting an extra layer of security. As someone who has helped evaluate packaging options firsthand, I always check for a clear label showing batch numbers, dates, and storage instructions. Reliable suppliers also go for food-grade liners, which means people downstream don’t discover foreign odors or improper seals. Lugging around a leaky drum or struggling with a soggy bag is not only a nuisance but a threat to both the warehouse and end user.

Shelf Life: Not Just a Number on a Label

Pharmaceutical sodium ascorbate comes with expectations. Under factory-sealed conditions, most batches last about two to three years. This number drops sharply if the product faces heat, humidity, or broken seals. From my time helping build pharma inventories, old or mishandled stock stood out immediately—clumped powder, musty smell, visual yellowing, and even lost potency. Quality control labs confirm this rapid decline once packaging fails or storage temperatures go over 25°C.

Here’s what industry best practice looks like. Warehouses keep this raw material away from direct sunlight and never stack anything over its head to prevent rips. Real storage usually means a dry room kept around 15°C to 25°C. Some buyers request oxygen-absorbing sachets or desiccants in every pack, because even small moisture infiltration speeds up degradation. Proper stock rotation helps too. Nobody wants to see expired raw material take up space—especially when recalls or costly destruction come into play.

Why Packaging and Shelf Life Can’t Be Afterthoughts

If someone overlooks packaging or shelf life, downstream consequences follow fast. A contaminated or expired input can taint a whole batch of finished products, force recalls, or worse, risk patient safety. Regulating agencies lay out tight standards for packaging integrity. In all the audits I’ve witnessed, inspectors dig deep, looking at packaging strength, labeling, traceability, and proof of shelf-life studies. Even small lapses, like a faded date or missing lot number, trip alarms. The better suppliers go beyond ticking regulatory boxes—they use high-bar packaging and regular stability testing, backing every claim with real data.

Errors show up fast in pharma. Shelf-life claims need backup: accelerated stability tests, real-time aging, proper documentation. Any supplier worth trusting shows this paperwork. And buyers always ask for certificates of analysis covering both purity and shelf life.

Improving the Process

Big improvements come from simple changes. Warehouses should train teams to spot damaged packaging and log any suspicious shipments straight away. Buyers can push for tamper-proof seals and insist on full traceability from their sources. Anyone placing a bulk order should get clear instructions on optimal storage and fast communication if packaging integrity ever lags. Even after years in the business, I believe there’s no substitute for hands-on inspections and strict logistics routines.

Sodium ascorbate’s stability and usability depend not just on chemical purity but on daily diligence from manufacturer to warehouse to product line. Good packaging and sound storage keep things safe—but only if the people handling it know what to look for and don’t cut corners to save on costs.

Sodium Ascorbate BP EP USP Pharma Grade
Names
Preferred IUPAC name Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-olate
Other names Sodium Ascorbate
Vitamin C Sodium Salt
Sodium L-ascorbate
Ascorbic acid sodium salt
Sodium Ascorbate BP
Sodium Ascorbate EP
Sodium Ascorbate USP
Pronunciation /ˈsəʊdiəm əˈskɔːrbeɪt ˌbiːˈpiː ˌiːˈpiː ˌjuːˈɛsˈpiː ˈfɑːrmə ɡreɪd/
Identifiers
CAS Number 134-03-2
Beilstein Reference 3561
ChEBI CHEBI:63626
ChEMBL CHEMBL1201532
ChemSpider 54657
DrugBank DB00126
ECHA InfoCard ECHA InfoCard: 03-2119431997-29-XXXX
EC Number 205-736-9
Gmelin Reference 7618
KEGG C00167
MeSH D020630
PubChem CID 518693
RTECS number **WS3060000**
UNII X50L779A7F
UN number UN3378
CompTox Dashboard (EPA) XT5K89807W
Properties
Chemical formula C6H7NaO6
Molar mass 198.11 g/mol
Appearance White to almost white crystalline powder
Odor Odorless
Density 1.66 g/cm³
Solubility in water Freely soluble in water
log P -9.5
Acidity (pKa) 7.73
Basicity (pKb) 8.92
Magnetic susceptibility (χ) Diamagnetic
Refractive index (nD) 1.62
Dipole moment 15.33 D
Thermochemistry
Std molar entropy (S⦵298) 146.4 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -635.5 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -1506 kJ/mol
Pharmacology
ATC code A11GA01
Hazards
Main hazards May cause eye, skin, and respiratory irritation.
GHS labelling GHS02, GHS07
Pictograms GHS07, GHS09
Signal word Warning
Hazard statements H319: Causes serious eye irritation.
Precautionary statements P264, P270, P301+P312, P330, P501
NFPA 704 (fire diamond) Health: 1, Flammability: 0, Instability: 0, Special: -
Autoignition temperature > 660°C
Lethal dose or concentration LD50 (oral, rat): >5000 mg/kg
LD50 (median dose) LD50 (median dose): 11,900 mg/kg (oral, rat)
NIOSH Not Listed
PEL (Permissible) PEL (Permissible Exposure Limit) for Sodium Ascorbate BP EP USP Pharma Grade: Not established.
REL (Recommended) Up to 1000 mg daily
IDLH (Immediate danger) Not established
Related compounds
Related compounds Ascorbic Acid
Calcium Ascorbate
Magnesium Ascorbate
Potassium Ascorbate
Sodium Ascorbyl Phosphate