What is 1-(2-Fluoro-6-Trifluoromethyl-Benzyl)-6-Methyl-1H-Pyrimidine-2,4-Dione BP EP USP Pharma Grade?

1-(2-Fluoro-6-Trifluoromethyl-Benzyl)-6-Methyl-1H-Pyrimidine-2,4-Dione, often referenced in industry conversations due to increasing relevance, stands out in pharmaceutical manufacturing for both its unique molecular structure and adaptability as a raw material. Pharma scientists routinely rely on this specific compound for synthesis reactions crucial to producing API intermediates. CAS numbers streamline database tracking, and experienced handlers immediately recognize the importance of working with documentation specifying not only the BP, EP, and USP grades, but also a detailed HS Code to ensure correct customs classification and compliance across borders. The foundation of safe handling comes from using trusted pharmaceutical raw materials, recognizing each property and hazard before scaling use in the lab or plant. Every kilogram handled enters a supply chain with real-world scrutiny on traceability and regulatory validation, which reinforces why accurate, honest content about this material matters for teams evaluating supply sources or insurers reviewing safe transport guidelines.

Chemical Properties and Characteristics

The chemistry behind 1-(2-Fluoro-6-Trifluoromethyl-Benzyl)-6-Methyl-1H-Pyrimidine-2,4-Dione is anything but simple. Its molecular formula, C13H8F4N2O2, underpins a dense framework, and any miscalculation in dilution or weighing can throw process chemistry off track. A serious synthesis lab relies on knowing the density — often measured around 1.49 g/cm³ — and whether the product arrives as a solid, powder, or crystalline flakes. Tactile experience tells that fine powders scatter easily; solid chunks demand sturdy scoops; crystalline forms offer slower dissolution but reward careful solvation with clear measurements. Color ranges from white to off-white, and handling provides immediate sensory confirmation, since subtle yellowing or clumping tells veterans about age or poor storage. In pure form, this compound resists easy melting, usually sitting above 170°C, which makes it perfect for rigorous reactions that need stable structures under heat or extended mixing.

Physical Forms and Storage

Experience in any synthesis lab shows the form of pharmaceutical compounds can be the difference between a smooth workflow and a week lost to troubleshooting. 1-(2-Fluoro-6-Trifluoromethyl-Benzyl)-6-Methyl-1H-Pyrimidine-2,4-Dione arrives as fine off-white powder, distinct pearlescent flakes, or in rare cases, crystallized beads or even suspended in tailored solvent solutions. Each lot requires carefully labeled storage, dry racks, and clear expiration dates. Specialists know even a slight uptick in ambient humidity during summer in non-climate-controlled storage risks solid clumps or uneven distributions, which later impact dosing precision. Bulk containers marked clearly with the HS Code and hazard warnings sit away from incompatible materials, especially acids or high-oxidizers, for obvious safety. Splash protection and local exhaust ventilation stand ready for each transfer and weighing, since even pharma-grade chemicals require a blend of respect for manual labor and trust in labeling accuracy.

Structure, Molecular Insights, and Reactivity

The molecule’s backbone, built on a pyrimidine-2,4-dione core functionalized with a 2-fluoro-6-trifluoromethyl-benzyl group, explains its coveted role in synthesis. This structure means chemists can leverage two points of reactivity — the electron-withdrawing trifluoromethyl group on the benzyl ring and the methyl at position 6 — to create diverse pharmaceutical scaffolds. Nearly every practicing organic chemist recalls the aftermath of a hasty reaction with under-characterized intermediates, leading to hours of instrument time spent chasing elusive side products. By using standardized, pharma-grade material with rigorous documentation, the guessing evaporates, letting synthesis teams plan for robust yields and reliable purities. The molecule thrives as a building block, giving manufacturers confidence to pursue new derivatives that extend medical therapies or unlock cleaner, more predictable process chemistry.

Specifications, Transport, Material Safety, Hazardous Concerns

Most senior procurement officers pay keen attention to specifications. For this compound, purity runs above 98% (HPLC), with strictly documented water content and minimal residual solvents flagged. Particle size consistency gets highlighted in audit calls, as clustering or fines lead to metering errors in continuous flow systems. Everything rides on accurate HS Code declaration, often 29335995 for customs and regulatory tracking. Alongside specs, safety is never theory — it’s lived experience. This compound, while not acutely toxic by trace exposure, always earns gloves, goggles, and mask use, and any spillage gets contained fast thanks to mandatory hazardous training. Material Safety Data Sheets read like checklists each time — flash point, environmental risks, inhalation symptoms. No station can afford slip-ups, as long-term dermal or inhaled exposure causes serious health impacts. Waste handling, always under local authority, usually follows incineration or deep burial to avoid environmental persistence, especially given the fluorinated content. The compound deserves respect, not just technical know-how.

Pharmaceutical Raw Material and Industry Impact

In my own experience with pharmaceutical development, raw material integrity stands central to productive research. Too many innovations have been cut short by impurities or inconsistent properties traced back to poorly validated intermediates. Using 1-(2-Fluoro-6-Trifluoromethyl-Benzyl)-6-Methyl-1H-Pyrimidine-2,4-Dione pharma grade closes that chronic loophole. Not only does it serve as a critical step in anti-viral or anti-inflammatory drug design, but it also sets a high standard for incoming inspection criteria, spectral libraries, and digital batch tracking. This is the background most chemists or production team leaders know by heart. Companies who invest in reliable sourcing discover not just fewer batch failures, but also smoother audits and easier regulatory filings, leading to faster launches and longer shelf stability. 

Solutions and Best Practices for Safe Handling

The solution to most pitfalls rests on respect for documented specs, ongoing vigilance in storage, and investment in continuous staff training. Teams that keep close tabs on temperature logs, humidity readings, and container integrity sidestep problems that less careful labs see again and again. Double-checking HS Code and purity at receipt cuts down the risk of regulatory fines or quarantine holds. Instituting batchwise analytical testing and environmental monitoring disciplines everyone in the plant, and fosters a real culture of care. Leadership that shares incident narratives — not just checklists — helps new hires understand that every drum carries years of knowledge and risk. In my own roles, I have seen diligent checking and documentation turn a warehouse full of potentially hazardous chemical stock into a strategic advantage, because regulatory authorities see not just compliance but real, documented stewardship of materials that have both therapeutic promise and environmental weight.