(1R,2S)-2-(3,4-Difluorophenyl)Cyclopropanamine(2R)-Hydroxy(Phenyl)Ethanoate BP EP USP Pharma Grade: Properties, Structure, and Applications

What is (1R,2S)-2-(3,4-Difluorophenyl)Cyclopropanamine(2R)-Hydroxy(Phenyl)Ethanoate?

Chemistry shapes daily life, but names like (1R,2S)-2-(3,4-Difluorophenyl)Cyclopropanamine(2R)-Hydroxy(Phenyl)Ethanoate sound distant before they step into the lab, the factory, or the health sector. This compound stands out among raw materials because its specific configuration unlocks unique interactions, central in pharmaceutical development and production. Developed to meet British Pharmacopoeia (BP), European Pharmacopoeia (EP), and United States Pharmacopeia (USP) pharma standards, it lands in high-stakes drug synthesis where the wrong twist or bend in a molecule can pivot outcomes from health to harm. Here, only the most precise chiral molecules pass through, and what rolls from the reactor must stand scrutiny at every checkpoint—by eye, by machine, by regulation.

Key Specifications and Molecular Structure

The structure of this molecule fuses a cyclopropane core with both difluorophenyl and hydroxy(phenyl) ethanoate groups. That cyclopropane ring, carrying two stereo-defined side groups, gives mechanical rigidity and determines how the compound fits its biochemical partners. Each atom slots in place: formula C17H16F2NO3, with a molecular weight that rests around 321.3 g/mol. Those two fluorine atoms—a signature of many modern pharma molecules—turn the compound into a sharper tool: fluorine resists metabolic breakdown, stretching the lifetime of the molecule inside the body and pulling the shape into tighter, more predictable forms. You find it as a solid in most conditions, and texture varies. In the raw, this material appears as a crystalline solid, which sometimes comes off the line as fine powder, sometimes as flaky shards, or on rarer orders as broader crystals tinged with faint white. Unlike sticky oils, it can be measured out by weight and poured easily, yet without the dust that clings to some lighter materials.

Physical Properties and Forms

Physical description tells a seasoned formulator how to handle a compound and how to anticipate real-world problems during mixing, transfer, or even quality control. This molecule holds a melting point that hovers in the solid-at-room-temperature zone, and remains stable under typical lab and warehouse environmental conditions. Density swings between 1.25 and 1.32 g/cm³, which means it feels denser than most organic powders but lighter than, say, metallic salts or oxides. In powder form, it stirs into solutions without floating clumps; in flake or crystalline state, it can be ground with mill or mortar, or fed directly to the production line for conversion into active pharmaceutical ingredients. It dissolves best in solvents like ethanol, methanol, or DMSO, and only sparingly in water. On the bench, under good lighting, the raw material looks almost like a fine sugar—dry, free-flowing, and not given to caking during short-term storage.

Chemical Codes, Storage, and Compliance

HS Code for international shipping: 29224995, found under ‘amino-compounds with oxygen function’. This code separates pharma-grade chemical traffic from more generic industrial shipments—a distinction that means customs looks closer, regulatory audits take longer, and need for traceability stretches back to the very first stock batch. BPA, EP, and USP grade guarantees a chain of custody, from synthesis using verified starting materials, high-purity solvents, and controlled conditions to rigorous impurity profiling by HPLC or spectroscopic confirmation. Storage asks for containers kept tightly sealed, shielded from direct light and humidity, and standing in areas marked for hazardous chemicals but not as high-priority toxins. Safe handling practices reflect a need for goggles, lab coats, and fume hoods—nobody likes an accidental whiff or dusting of material that could set off skin or respiratory irritation. Labels sit clear on every drum and small bottle: “hazardous if swallowed or inhaled, harmful with prolonged exposure.”

Safety, Hazards, and Environmental Impact

Raw materials in pharma aren’t just potential. Their hazards echo long after batch records close. This compound carries warning tags for acute toxicity if mishandled—mainly by inhalation or skin contact. I’ve seen too many techs skip gloves, then struggle with rashes or respiratory symptoms. Safety sheets reflect reality: avoid dust formation, work with small open batches under local exhaust, quarantine spills promptly, and manage waste according to local regulation—never down the drain. Emergency showers, eye wash stations, and first-aid kits stand closer to raw material staging areas than most folks realize. It’s not heightened paranoia, just the practical reality of keeping a team healthy, batch after batch.

Applications and Importance in Pharmaceuticals

The route from raw material to finished pharma product draws from compounds like this. Medicinal chemistry teams pick chiral amines and hydroxy derivatives strategically to build complex drugs: anti-depressants, anti-virals, pain relievers, or central nervous system agents. The ring strain of cyclopropane, mixed with the electronic push-pull from difluorophenyl, guides binding to body targets that blander molecules miss. The right configuration helps turn a basic chemical into a life-changing tablet after formulation, encapsulation, and stability testing. The importance of such well-characterized intermediates can’t be overstated—one unvetted contaminant, one misidentified isomer, derails months or years of development work. The regulatory pressure is just part of the science.

Continuous Improvement and Solutions

On the production floor, problems usually start small: powder handling losses, static charge during transfer, solubility headaches in bulk mixing. Fixes come from experience—anti-static mats, controlled humidity warehouses, improved granule forms or tailored crystal habits that cut waste and reduce exposure. Safety pushes don’t end with paperwork. Training and real-life drills matter far more than binders on a shelf; knowing how to respond when a container leaks, or which mask fits for dust versus vapor exposure, protects teams and product quality. Reliable vendors who document molecular weight, purity, and batch sterility win repeat contracts, while cut corners in traceability or safety backfire, tarnishing end-product trust. Manufacturers open new territory by exploring less hazardous analogs without sacrificing efficacy, dialing up the green chemistry quotient, and implementing better solvent recycling or waste minimization steps every year. In the end, every granular improvement in safety, process handling, and product purity doesn’t just keep a factory humming—it shapes medicines and, by extension, the health outcomes upstream and down.