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2-[[(3Ar,4S,6R,6As)-6-[[5-Amino-6-Chloro-2-(Propylthio)-4-Pyrimidinyl]Amino]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Yl]Oxy]-Ethanol BP EP USP Pharma Grade stands out as a specialty raw material across the pharmaceutical and chemical industries, relying on strict quality standards to maintain both purity and consistency. The product derives its backbone from a pyrimidine ring—known for forming the basis of various antiviral and immunosuppressive medications—modified further with an amino group, chlorine atom, and a propylthio chain, bringing distinct properties to this molecular structure. Manufacturing under British Pharmacopoeia (BP), European Pharmacopoeia (EP), and United States Pharmacopeia (USP) standards means a close eye tracks its specification, from molecular integrity and elemental composition to impurity counts. Companies and professionals depend on that reliability, as even slight deviations in content or texture can affect product effectiveness or safety. The inclusion of cyclopenta-dioxolane rings, along with the attached oxyethanol moiety, allows for increased solubility in water and organic solvents, and that adaptation leads to easier formulation for liquid and solid dosages alike.
Taking a closer look at this compound’s properties, the molecular formula reflects a complex arrangement of carbon, hydrogen, nitrogen, oxygen, sulfur, and chlorine atoms. Laboratory analysis often shows a white to off-white appearance, with solid forms taking on powder or crystalline characteristics, though in some controlled storage environments, flakes or pearls can form depending on the technique used for precipitation or drying. The density typically settles near 1.2 to 1.4 g/cm³, a figure influenced by the amount of cycloalkane content and the substituents installed on the pyrimidinyl core. This material resists breakdown below standard pharmaceutical processing temperatures, providing thermal stability for formulation but also demanding handled care to prevent accidental decomposition or loss of active molecular groups. The melting point generally sits in the range of 185–200°C, a tidy result for a molecule offering both flexible reactivity and shelf life under proper storage conditions. In solution, the chemical maintains high purity, verifiable by HPLC and NMR analytical data, which show each peak and signal exactly where they belong on the spectrum—a far cry from the inconsistency found in industrial-grade analogues. Agronomists and medical chemists alike appreciate materials like this for their balance between stability and reactivity.
Shipments most often arrive in vacuum-sealed or nitrogen-purged containers to guard against oxidation and moisture absorption, critical steps for upholding the product’s specifications over time. Ask anyone working in pharmaceutical QA and they’ll attest that minuscule changes in humidity or packaging lead to caking, color changes, or drops in potency, so a simple plastic jar won’t cut it. Instead, industry relies on packaging tailored to shield the raw material from light, air, and temperature shifts, serving not only the letter of pharmacopeial law but also daily reality in busy labs. For larger volumes, suppliers provide drum or intermediate bulk containers, always lined with insider films or foil barriers. Inside, the raw material may appear as free-flowing powder or tightly packed crystalline flakes, each batch’s particle size dictated by its synthetic route and standardization runs. No one expects the same product to serve both injectable and tablet forms, so producers support a spectrum of grades defined by solubility, flow, and density.
Across international supply chains, proper HS Code classification is a non-negotiable detail. This compound most often qualifies under HS Code 293359, marked for “heterocyclic compounds with nitrogen hetero-atom(s) only,” capturing the core chemical identity for customs processing. Compliance here isn’t an afterthought: improper labelings can delay shipments for months or even result in seizure, interfering with production timelines and affecting patient care. Tracking the source, documentation, and intended application of this compound means transparency for importers, government inspectors, and downstream buyers. Regulatory requirements extend well past customs paperwork. Batch-specific certificates of analysis, impurity profiles, and handling guides must match the latest BP, EP, or USP standards, from purity percentages—often confirmed at more than 99%—to precise limits on residual solvents, inorganic impurities, and microbiological contamination. For pharmaceutical manufacturers, breaches in these standards can trigger recalls or loss of license, so legal and regulatory vigilance isn’t optional.
A proper safety approach to 2-[[(3Ar,4S,6R,6As)-6-[[5-Amino-6-Chloro-2-(Propylthio)-4-Pyrimidinyl]Amino]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Yl]Oxy]-Ethanol starts with its status as a hazardous chemical under GHS (Globally Harmonized System). Whoever handles this raw material, whether as a powder, crystal, or in diluted liquid form, counts on site-specific protocols designed to prevent toxic exposure. The amino-chlorine-pyrimidine motif underpinning this molecule can irritate skin, eyes, and respiratory passages, and full PPE remains standard—think nitrile gloves, goggles, and splash-proof coats, plus direct ventilation in confined spaces. Spills demand immediate clean-up using non-sparking tools and proper absorbents, since the compound’s powder can aerosolize and cause respiratory distress. Safety Data Sheet (SDS) documentation highlights risks from combustion or thermal breakdown, with harmful gases such as nitrogen oxides, sulfur oxides, and hydrochloric acid possible in fire situations. Given its raw material status, local and national environmental disposal laws apply too; improper dumping can spark fines or environmental damage, so waste handling routes rely on certified hazardous material vendors—not household drains.
What makes this compound more than another chemical in a catalog comes down to its molecular structure. That blend of a tetrahydrocyclopenta-dioxolane ring fused with a functionalized pyrimidine supplies both rigidity and receptor specificity, a major step up from simpler organic molecules that lose effectiveness under metabolic stress. Researchers and formulators turn to this class of raw materials for new molecular entities (NMEs) or as intermediates in established drug syntheses, banking on structural motifs designed to bind specific enzyme targets or block viral replication. The presence of multiple chiral centers forces careful handling during synthesis, purification, and analytical confirmation since the wrong isomer can mean the difference between therapy and toxicity. Analytical teams run extensive NMR, HPLC, and MS scans to confirm both stereochemistry and batch purity. Real-world use cases range from investigational antivirals to specialty immunosuppressives, reflecting years of medicinal chemistry work and competitive clinical results.
Dangers linked to improper use or disposal go beyond the workplace health impacts. Given its reactivity and persistence, this compound can remain in environmental water streams or soil, posing risk to aquatic life or bioaccumulating higher up the food chain. Responsible action starts well before purchase, with buyers checking supplier certifications for ISO, GMP, and environmental management. Many companies pursue green chemistry approaches, seeking process tweaks or supply routes to reduce total environmental footprint, minimize hazardous byproduct outputs, and ensure input materials come from verified, low-impact sources. Anyone working with or selecting suppliers for BP EP USP pharma grade materials should investigate supply chain sustainability, not just price or volume. Responsible sourcing helps protect both workplace safety and global ecosystems.
With stricter pharmaceutical regulations and growing calls for supply chain transparency, the market for high-purity, well-documented pharmaceutical raw materials keeps evolving. Automated analytics, real-time impurity detection, and blockchain-based material tracking enter regular workflow, building a digital chain of custody from initial synthesis to end user. This isn’t just a trend; as recent recalls and contamination scares show, weak points in sourcing or certification put both patient health and company reputation at risk. Any pharmaceutical firm—no matter the country or field—will invest in traceable, peer-reviewed chemical inputs if it means avoiding disaster. For a molecule as complex and versatile as 2-[[(3Ar,4S,6R,6As)-6-[[5-Amino-6-Chloro-2-(Propylthio)-4-Pyrimidinyl]Amino]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Yl]Oxy]-Ethanol, that attention to both science and stewardship carves out a stronger, safer future for medicine and industry alike.
Chengguan District, Lanzhou, Gansu, China
