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2-Hydroxypyridine N-Oxide BP EP USP Pharma Grade forms part of a class of pharmaceutical raw materials with a wide roster of applications in the synthesis of more complex molecules and as a reagent within pharmaceutical research. This material, by meeting stringent international standards—including British Pharmacopoeia (BP), European Pharmacopoeia (EP), and United States Pharmacopeia (USP)—holds up to the highest scrutiny for safety, traceability, and purity. Chemists recognize it for its role as an intermediate or starting material in both laboratory and industrial contexts, where reliability and reproducibility play key roles in product development and regulatory submission.
2-Hydroxypyridine N-Oxide shows up with a unique molecular structure, built on the pyridine ring. The molecular formula stands as C5H5NO2, and the molecule itself includes a hydroxyl group attached to the second position of the pyridine and an N-oxide functional group bonded to the nitrogen atom of the ring. This arrangement gives the compound a set of chemical and physical attributes that set it apart from simple pyridine derivatives. The N-oxide moiety, in particular, brings about changes in reactivity, enabling new chemical transformations and enhanced stability during pharmaceutical manufacturing processes. Crystallographers often describe the material as a solid crystalline compound, with flakes, powder, pearls, or, less commonly, a granular or specific particulate form under industrial handling.
Under normal conditions, 2-Hydroxypyridine N-Oxide presents as an off-white or pale yellow solid, displaying a dense crystalline appearance. It resists deliquescence, which makes storage and handling simpler for anyone used to tracking down moisture-sensitive chemicals in the lab or production floor. The density typically falls within a range near 1.3 to 1.4 g/cm3 in its solid state, with melting points hovering near 150°C, though slight variation often results from different manufacturing routes or purification steps. Unlike some aromatic raw materials, this compound manages a balance between solubility in water and select organic solvents, making it adaptable for solution-based protocols or when dissolved for chemical reactions or titrations. Pure material rarely emits a strong odor, making workplace monitoring for vapors less demanding compared to some pyridine relatives. Chemically, stability holds up under room temperature with proper containment and away from incompatible agents like powerful oxidizers or strong acids. The compound’s N-oxide function improves its oxidative stability, and synthetic chemists put it to work as a ligand or nucleophile.
Compliance with BP, EP, and USP guidelines brings expectations for extremely low residual solvents and controlled heavy metal content. Impurities, including related pyridine derivatives or oxidized byproducts, receive tight scrutiny by HPLC and titration. Lot-to-lot consistency forms the backbone of supply chain confidence and supports documentation required in regulated pharmaceutical manufacturing. Particle size, purity—often 99% or higher—and identity confirm by NMR, IR, and elemental analysis; suppliers typically provide certificates of analysis for each batch. Quality programs that drive global pharmacopeia compliance rely on identification, assay, and chromatographic purity as key specifications, both for API intermediates and as reagents within GMP processes. The material’s HS Code, for international movement and customs compliance, generally registers under 2933.39, encompassing heterocyclic compounds with nitrogen hetero-atoms.
Distribution often includes flakes, free-flowing powders, crystalline lumps, or pearled granules. Each physical form caters to particular process requirements—from direct solution in solvents for wet process chemistry to easy weighing and transfer in solid-handling operations. Large pharmaceutical firms or chemical manufacturers order in fiber drums, plastic-lined containers, or, for small volumes and R&D, amber glass or high-density polyethylene bottles. Units measure by both weight (gram, kilogram) and, in solution applications, volume (liter) for ready-to-use liquid formulations. Secondary containment and tamper-proof seals keep buyers confident about product integrity during transit and storage.
Safety data sheets for 2-Hydroxypyridine N-Oxide give details on chemical hazards, health and environmental risks, and proper waste management. While the compound exhibits moderate toxicity, it avoids the extreme acuteness of more reactive pyridine derivatives. Standard chemical hygiene applies—use in a well-ventilated fume hood, avoid contact with skin and eyes, and prevent ingestion. Chronic occupational exposure should stay minimal, as repeated handling could carry a risk of dermal or respiratory sensitization. Emergency protocols focus on spill cleanup using absorbent material and immediate containment. Disposal as hazardous chemical waste adheres to local and national regulations. The compound’s environmental profile, though not as persistent or bioaccumulative as many legacy organics, still commands best practice around containment and effluent management, especially where pharmaceutical manufacturing overlaps with water treatment or sensitive ecosystems. The N-oxide group resists simple biodegradation, so engineered waste treatment solutions remain necessary to guard against inadvertent release.
Within pharma manufacturing, this compound steps in during key synthetic transformations, often acting as a mild oxidant or as an intermediate poised for more extensive chemical elaboration. Organic chemists value its clean reactivity, limited sidereactions, and ability to be purified and handled with fewer precautionary restrictions than many alternative pyridine-based reagents. This performance underpins its popularity where high-purity input leads directly to active drug substances, specialty fine chemicals, or advanced research projects. Investment in improved synthetic access and purification reflects industry pressure for greater transparency and minimized risk—regulatory trends always push toward clear documentation around every raw material. The more reliable the input, the greater the confidence in the therapeutic output.
Consistent supply routes, supplier audits, and ongoing quality control define the roadmap for 2-Hydroxypyridine N-Oxide BP EP USP Pharma Grade in modern pharma or research settings. Staff training in chemical risk management and rigorous adherence to storage and transport instructions make practical sense. Manufacturers who keep lines open with suppliers and invest in analytical verification dodge most surprises. Technologies such as real-time monitoring of storage conditions, barcode-based inventory control, or digital batch tracking improve traceability, especially when compounded drugs or high-stakes clinical products rely on these precursor chemicals. Innovation around waste minimization, recycling, or green chemistry approaches also finds room for growth, both to meet regulatory targets and to reduce operational risk tied to hazardous material handling or environmental liabilities. Open dialogue between supply chain, technical, and EHS teams ensures 2-Hydroxypyridine N-Oxide remains a valuable, manageable, and resilient component in pharmaceutical progress.
Chengguan District, Lanzhou, Gansu, China
