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3-Chloropropiophenone, a chemical compound found in pharmacy and industrial labs, steps forward as a crucial ingredient for multiple syntheses and chemical processes. Displaying a unique profile, this molecule carries the scientific name 1-(3-chlorophenyl)propan-1-one. The 'BP', 'EP', and 'USP' tags highlight its compliance with British, European, and United States Pharmacopeia standards. This adherence matters for anyone keen on pharmaceutical purity, secure sourcing, and controlled application in sensitive clinical environments. Every researcher and procurement officer who has handled solvents and reagents knows shortcuts don’t make sense where safety comes into play. With a core structure built around a propiophenone backbone bearing a chlorine atom on the meta position, 3-Chloropropiophenone acts as a pivot for a variety of downstream products, acting as a base, intermediate, or precursor for complex molecules.
The appearance varies based on processing and storage but generally presents as white to pale yellow crystalline flakes or a fine powder, sometimes forming larger pearl-like granules. Some batches have been observed melting into a viscous, denser liquid if kept above room temperature for an extended period, testament to a melting point that sits in the ballpark of 38 to 41 degrees Celsius. Its molecular formula reads C9H9ClO, with a molar mass of 168.62 g/mol. Density often checks in at around 1.2 g/cm³, which points to a heavier solid structure compared to simple hydrocarbon-based organics. Most chemists picking between solid and liquid form know that density and melting point set the tone for how to handle and store each drum or vial. Solubility patterns in water remain low, hinting at hydrophobic character but dissolve readily in organic solvents like ethanol, acetone, and ether.
Peering into the molecule’s structure unveils a simple ketone on the propiophenone scaffold, with chlorine attached at the third position along the phenyl ring. The presence of the ketone group, a hallmark of this compound, grants reactivity in nucleophilic addition and reduction pathways, while the aromatic fragment creates opportunities for direct substitution or further functionalization. Maintainers in production plants rely on such structural predictability to streamline workflow and anticipate reactivity in scale-up operations. By referencing the precise arrangement of bonds and atoms, chemists secure batch-to-batch reliability even when shifting vendors or adjusting synthesis plans.
Each technical sheet lays out clear markers for purity, melting point, and maximum thresholds for related impurities, including chlorinated byproducts and excess solvents. Typical pharma grade requires a content of not less than 99% by HPLC or GC, with limited moisture (usually under 0.5%) and restrictive levels of heavy metals. These practical cutoffs serve anyone loading reactors or prepping formulations, as an extra percent in purity cuts headaches caused by cross-contamination or unplanned side reactions. Standard packaging ships in double-sealed plastic or amber glass to block light and humidity, ensuring materials remain stable during transit and warehousing.
International supply chains recognize 3-Chloropropiophenone under the Harmonized System (HS) Code 2914.39, which covers aromatic ketones such as acetophenone derivatives. Clearing customs or working through permits calls for accurate HS labeling, and anyone negotiating overseas shipments pays attention to this step. Import and export documentation rides on transparent labeling, and errors in declaration can result in border delays or penalties. Experience dealing with chemical logistics highlights the need for precise, up-to-date labeling to avoid holdups that impact laboratory schedules and downstream customer expectations.
Safety data on 3-Chloropropiophenone identifies several hazards. Contact might irritate skin, eyes, or mucous membranes, while inhalation or ingestion risks central nervous system symptoms such as headaches, dizziness, or drowsiness. Many production facilities rely on standard protocols—gloves, goggles, fume hoods, and careful workplace labeling—to avoid direct exposure. Beyond PPE, trusted chemical suppliers provide clear SDS paperwork describing spills, fire behavior, reactivity, and first aid essentials. Flammable characteristics call for controlled storage, usually in ventilated cabinets, away from oxidizers and strong acids. From early days in research settings to scaling up manufacturing, any mishandling could prompt chemical burns, inhalation injury, or even more significant toxic events. Proper training and signage guide seasoned and new staff toward mindful material handling and waste disposal.
3-Chloropropiophenone often finds its way into synthesis protocols for pharmaceutical intermediates, specialty polymers, dyes, and experimental analytical chemistry. As a building block, the presence of the chlorine atom and reactive carbonyl unlocks routes for nitration, halogen exchange, and chain extension. Raw materials for synthesis—such as 3-chlorobenzene and propionyl chloride—also warrant quality oversight, as lapses in their grade circulate defects downstream. Experienced purchasing agents seek out vendors with transparent traceability, batch certification, and quality assurance paperwork. For entities driven by cost management, balancing lower prices with unwavering safety and clean audit trails stays top of mind. It’s not unusual to encounter pressure to cut corners, but the long game always favors integrity in raw material sourcing.
This compound requires careful disposal, as improper handling releases harmful chemicals into the environment. Disposal workers depend on incineration at high temperature in controlled facilities to break down the molecule safely, blocking any chance of ground or water contamination. Cyanide or chlorine-containing substances emerge as byproducts so the added step of post-combustion scrubbing enters standard landfill management. Seasoned labs and manufacturers document their disposal routines, holding onto manifests and receipts to confirm compliance during regulatory checks or in response to community inquiries. Embedding environmental stewardship into chemical work isn’t just about meeting regulations; it builds resilience and community trust over time.
3-Chloropropiophenone BP EP USP Pharma Grade stands as a practical and powerful component in both industrial and pharmaceutical chemistry. Its clear molecular identity, precise grading, and strict handling requirements give users a roadmap for better, more responsible chemistry. Those who invest in knowing and respecting this material’s properties—rather than glossing over the details—yield dividends in product quality, safety, and lasting reputational strength. The story of 3-Chloropropiophenone lives at the crossroads of science, common sense, and responsible industry stewardship.
Chengguan District, Lanzhou, Gansu, China
