4,6-Dichloro-2-Propylthiopyrimidine-5-Amine BP EP USP Pharma Grade: Material Profile and Industry Insights

What is 4,6-Dichloro-2-Propylthiopyrimidine-5-Amine?

4,6-Dichloro-2-Propylthiopyrimidine-5-Amine, commonly used in the pharmaceutical industry, carries a distinctive pyrimidine backbone with two chlorine atoms located at the 4 and 6 positions, a propylthio group bonded at the 2-position, and an amine function on the 5-position. Its molecular formula is C7H9Cl2N3S, giving a clear insight into its atomic composition. Tightly regulated across USP, EP, and BP specifications, this compound shows a unique profile that balances between desired reactivity and stability. As a raw material, it supports development of active pharmaceutical ingredients (APIs), and researchers have found this chemical in both developmental labs and production settings. Real-life experience highlights its crucial function in multiple drug synthesis pathways, where its amine and thio groups drive important substitution reactions.

Physical Properties and Characteristics

This compound shows up mostly as a crystalline solid, with appearances ranging from powder and flakes to rare larger crystal or pearl formations. Density comes in at approximately 1.42 g/cm³, which I’ve found lines up with expectations for similar halogenated pyrimidines. Its melting point normally falls in the intermediate range—solid enough for stability, but also easy to process with standard laboratory heating equipment. The solid form’s muted beige or off-white color signals its relative purity, yet any sign of grey or brown tinge often flags contaminants that could compromise final product quality. In storage and handling, absence of strong odors helps during raw material management tasks, though its volatility at higher temperatures calls for vigilance.

Chemical Structure and Implications

Looking at its structure, the pyrimidine ring serves as a versatile building block in medicinal chemistry. Two chloro substituents at pyrimidine positions 4 and 6 confer significant electron withdrawing effects, making the ring less reactive toward unwanted side processes. The propylthio group adds both hydrophobicity and specificity to its reactivity, influencing both solubility in non-polar solvents and its fit in target molecules. The amine at position 5 presents chemists an anchoring point for future modification, vital when tailoring drug molecules for selectivity and potency. In practice, this structure builds in both flexibility and performance, cutting across small-scale research and industrial bulk synthesis.

Specification, HS Code, and Regulatory Context

Trade and regulatory compliance require precise information: with an HS code typically falling under 2933 for heterocyclic compounds, 4,6-Dichloro-2-Propylthiopyrimidine-5-Amine clears customs as a specialty pharmaceutical material. Each batch must meet strict BP, EP, and USP protocols—purity surpassing 98% by HPLC, identification through IR and NMR, plus residual solvents and elemental impurities below pharmacopeial thresholds. Every analytical chemist in pharma faces this checklist. The need for full traceability—from raw material arrival to the finished drug—stresses the critical nature of documentation and chain-of-custody systems. In my own work, careful alignment with these specifications has shielded projects from regulatory setbacks and costly recalls.

Material Forms: Solid, Powder, Crystals, and Pearls

Manufacturers supply 4,6-Dichloro-2-Propylthiopyrimidine-5-Amine in dense, free-flowing powder for easy blending, or compressed into flakes or small crystalline pearls to limit dust formation in large-scale processing. Each form brings its own advantages. Powder offers maximum surface area for fast dissolution. Flake and crystal forms work better in continuous flow systems. I’ve noticed that end-users appreciate stability in storage; pearls and flakes reduce risk of atmospheric uptake and clumping. Consistent particle size and dryness are crucial for pharmaceutical blending, because even small shifts in moisture or particle size distribution can ruin a batch of tablets or capsules.

Solubility, Safe Handling, and Hazardous Concerns

Solubility in organic solutions remains moderate due to the compound’s heavy halogenation and thio substitution. Water solubility stays low, which limits accidental spread but also means solvents like dichloromethane or ethanol see more use during synthesis. Toxicological data point to moderate acute and chronic hazards—its chloro and thio functionalities bring skin and respiratory tract irritation risks, plus potential harmful effects with prolonged exposure. In my career, I’ve guided teams to handle this chemical only inside ventilated enclosures equipped with carbon filtration. Gloves, goggles, and protective suits form a standard line of defense. Emergency eyewash and spill containment plans—backed by material safety data sheets—keep operators protected should accidental exposure or spillage happen. Training staff on these risks prevents both health hazards and production downtime, which always matters on a tight schedule.

Raw Material Role and Industry Value

This compound stands as more than just another line item in a chemical inventory. Its application as a raw material in drug development and specialty chemical production offers a foundation for a range of active molecules with anti-infective, anti-cancer, and neurologically active properties. Purity and consistency grant process engineers deeper control over manufacturing outcomes, while its unique chemical reactivity sets a reliable stage for innovative research in both old and new therapeutic areas. Industry demand stays robust and steady, especially as new generations of pyrimidine-based drugs enter clinical stages. Drawing on real-world feedback, I’ve seen how robust supply and transparent specification management protect both project budgets and patient safety.

Solutions and Future Direction

Ongoing industry dialogue focuses on sustainable manufacturing—green chemistry practices and safer handling protocols. Suppliers are working toward lower-residue synthesis routes and improved waste treatment, which can minimize hazardous by-products. Analytical technologists continue to refine detection and monitoring systems; inline spectroscopy and faster batch release workflows look set to reduce manufacturing lead times. Training personnel to spot early signs of degradation, both visually and with analytical gear, will curb waste and avoid dangerous surprises in production. Strong partnerships across global regulatory, supply chain, and manufacturing teams are shaping the future for high quality, safe, and efficient use of 4,6-Dichloro-2-Propylthiopyrimidine-5-Amine in an increasingly complex pharmaceutical landscape.