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6-Bromo-4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[D]Imidazole shows up as an essential intermediate during the synthesis of abemaciclib, a targeted cancer therapy from the family of CDK4/6 inhibitors. Often specified for advanced breast cancer treatment, abemaciclib relies on high-purity raw materials through every synthetic step. This intermediate, tagged confidently by its IUPAC name and recognized through pharma standards like BP, EP, and USP, draws attention for its precise structure and tightly controlled properties. You’re working with a molecule shaped by both its aromatic benzimidazole core and its four distinct substituents—bromine at position 6, fluorine at position 4, isopropyl at position 1, and methyl at position 2. Each substitution steers the intermediate’s reactivity and ultimately determines the product’s reliability and safety down the line.
Materializing most often as pale crystalline solid, 6-Bromo-4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[D]Imidazole delivers a unique set of physical traits. The crystalline habit of the powder or flakes indicates a well-ordered molecular arrangement—a frequent expectation for pharma-grade intermediates where purity and handling ease matter. The density typically ranges from 1.4 to 1.6 g/cm³, influenced in part by the heavy halogen atoms and the benzimidazole backbone. No distinct color or odor distracts workers or quality control teams, lowering contamination risks. Handling the substance feels straightforward—no excessive static charge or clumping, aiding accurate weighing and transfer. In the lab, the substance resists degradation under standard storage, blocking hydrolysis or oxidation under dry, room-temperature conditions. Low solubility in water can challenge direct solution preparation, pushing chemists toward organic solvents such as DMSO, acetonitrile, or DMF for reactions and analyses. As a solid, it pours out as grains, flakes, or sometimes a microcrystalline powder, with little dust that affects inhalation risk, though standard GMP guidance always prioritizes safety glasses and gloves with all fine chemicals.
This intermediate stands out by its molecular formula: C12H12BrFN2. Its molecular weight hovers around 283.15 g/mol, dictated by both halogen and heterocycle atoms in the core. Chemical specifications commonly demand a purity of over 98%, confirmed through methods like HPLC and NMR. Consistent melting points—often between 118°C and 125°C—act as a fingerprint helping analysts to verify identity batch after batch. The HS Code for customs and global trade often falls under 29339900 (heterocyclic compounds with nitrogen hetero-atom(s) only), facilitating tracking, compliance, and tariff application across borders. Stability as a raw material relies on tight packaging, minimal exposure to moisture, and correct labeling per GHS guidelines for both industrial and research supply.
The chemical introduces a mix of safety concerns characteristic of synthetic organics. Harmful if inhaled or swallowed, the intermediate calls for controlled access, mechanical ventilation, and PPE where open handling takes place. Eye or skin contact risks an irritant response—so splash-resistant goggles and nitrile gloves show up as standard. As a non-volatile compound, risk of inhalation exposure drops but dust suppression and local exhaust still matter. Labels and shipment documentation flag the hazard pictograms drawn from GHS standards, and every drum or bottle ought to carry instructions for safe storage. In case of spillage, typical lab practices with damp cloths or vacuuming minimize airborne dust, and proper waste disposal ensures facility safety. On larger scales, the intermediate stays away from open flames—brominated organics can release hazardous byproducts under heat or fire, meaning every production line needs accessible extinguishers and emergency planning.
Used as a crucial raw material, 6-Bromo-4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[D]Imidazole allows production lines to build the abemaciclib molecule one atom at a time with precision. Any contamination or unexpected byproduct formation during the intermediate’s synthesis can domino into later steps, threatening the final drug’s purity and ultimately patient safety. I've seen manufacturers conduct batch-by-batch traceability, using detailed analytical profiles and supply chain records, to cut out even the smallest chance of error. Keeping the structural integrity of the intermediate intact depends on rigorously enforced supplier qualification, with secondary analytical confirmation performed in independent laboratories. In production environments, synthetic chemists watch for changes in physical properties—such as flow, melting behavior, and color—since subtle shifts provide early warning for process drift or storage problems.
One lesson learned from years near GMP chemistry: the value of traceable, transparent sourcing. Pharmaceutical producers demand not just a certificate of analysis, but proof of compliance with international regulations. Documentation traces the route from raw input through each stage of conversion, packaging, and shipment. Data integrity and lot-to-lot consistency strengthen the trust between supplier, regulator, and manufacturer. Regulatory filings reflect molecular weight, formula, melting point, and impurity levels, as well as the HS Code and hazard classification for every kilogram shipped. Pharmaceutical regulators lean on that detailed property sheet to approve import and usage—no guesswork allowed when health outcomes ride on molecular certainty.
Improving supply chain resilience and chemical safety in the pharmaceutical sector calls for more than technical know-how; it means forging constant dialogue between manufacturers, suppliers, shippers, and end users. Standardized purity testing, routine audits, on-site inspections, and transparent documentation create a barrier against supply chain contamination and accidental exposure. Encouraging real-time tracking of storage conditions and chain-of-custody reporting further shrinks risks tied to unexpected environmental changes or handling mistakes. Manufacturers move toward full digital traceability, barcoding each drum, tracking every lot through production, and using automated alerts for deviations. Scientists, suppliers, and regulators who stay informed about the latest research on chemical handling—who read continuously, who attend workshops—bring the right blend of caution and care to every batch of 6-Bromo-4-Fluoro-1-Isopropyl-2-Methyl-1H-Benzo[D]Imidazole moved through the global system, directed with sharp precision toward lifesaving outcomes.
Chengguan District, Lanzhou, Gansu, China
