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Aluminum acetylacetonate belongs to the family of coordination compounds, bringing together aluminum metal and acetylacetonate ligands. This specialty chemical, with the formula C15H21AlO6 and CAS number 13963-57-0, shows up in pharmaceutical manufacturing and research settings. Its BP, EP, and USP tags signal that the compound lines up with three leading pharmacopeial standards — British Pharmacopoeia, European Pharmacopoeia, and United States Pharmacopeia — meaning it ticks all the right boxes for consistency, purity, and safety that the pharmaceutical world expects.
In the real world, aluminum acetylacetonate comes as a solid, with fine powder, crystalline flakes, and sometimes small, pearl-like granules—smooth to the touch, dry to the eye, white or faintly ivory depending on grade. This is not a gooey chemical; you’ll never find it as a liquid or in oily form. Its solid make-up lets suppliers pack it into moisture-proof drums or high-density polyethylene bottles, protecting the content from water, dust, and everything else that doesn’t belong. These varied shapes don’t just look different; users pick one for its compatibility with their own blend, thickness, or the way a powder might dissolve compared to chunky crystals.
Every molecule tells a story. Here, one trivalent aluminum ion bonds with three acetylacetonate ligands, wrapping metal and organic segments into a stable ring structure called a chelate. This bonding pattern gives the compound a firm grip on its own aluminum atom. Chemically, it stands at C5H7O2)3Al. Its relative formula mass lands around 324.3 g/mol. Anyone in quality control or regulatory review cares about that clarity — the very building blocks that dictate how the compound behaves under process or storage.
Aluminum acetylacetonate carries a melting point usually between 190 and 195 degrees Celsius, putting it safely outside of the risk zone in ordinary transport or storage. The density runs around 1.31 grams per cubic centimeter (g/cm3), giving it enough heft to mix reliably into tablet blends or liquid suspensions. It shows low solubility in water but responds much better to organic solvents such as ethanol or acetone. No taste, no smell—this is how chemists like it. The compound resists moisture; exposed to air, it won’t clump up or degrade all at once. In a laboratory, that reliability counts for a lot.
Freight, trade, and border agencies want the right customs information. The harmonized system code (HS Code) for aluminum acetylacetonate usually sits at 2933.59.90. This numeric code helps streamline import and export filings, ensures the product lands with proper declarations, and lines up with rules across North America, Europe, and Asia. Each delivery needs secure paperwork: Certificate of Analysis, grade specification, and safety data sheet that matches the BP EP USP requirements down to each digit.
In pharma, this compound doesn’t work on its own; it steps in as a reagent, catalyst carrier, or complexing agent. It can stabilize intermediates, lend its aluminum content to synthesis reactions, or act in processes that demand non-water-soluble sources of aluminum. Beyond pills and vials, the material sometimes drifts into laboratory glass-coating, certain cosmetic formulations, and as a research feedstock. The raw materials—acetylacetone and a soluble aluminum salt—run through controlled reactions under heat and stirring. Manufacturers watch for tight specifications: no unwanted metals, low moisture, and a particle size that mixes efficiently in high-speed batch production.
Safety data leaves no room for shortcuts. Aluminum acetylacetonate generally carries low acute toxicity by oral or dermal routes, but it can cause irritation after prolonged contact or inhalation of dust. In pharmaceutical plants, gloves, goggles, and dedicated dust masks remain standard. Chemical safety labels place this compound under the "harmful if inhaled" warning, and every operator in a pharmaceutical company gets familiar with the material’s risk phrases. Spillage calls for dry cleanup — sweep rather than hose — and disposal follows national chemical guidelines, barring the material from drains and open soil. Storage means cool, dry, and shaded shelves, away from oxidizing agents or strong acids.
Consistency in raw material quality shapes the very pillars of modern pharma production. Aluminum acetylacetonate seems humble on paper, but it shows how tight control over chemical properties makes safe medication possible. Incomplete records or an off-spec batch could undermine a whole production run. Many pharmaceutical professionals advocate for quarterly internal audits, validated analytical methods, and supply chain transparency right down to raw input source—practices that guard against cross-contamination, unexpected impurities, or rogue suppliers.
Future challenges surround improved traceability, green chemistry sourcing, and packaging standards that keep both workforce and environment safer. As pharmaceutical regulations tighten in regions like the EU and North America, companies might press for tighter impurity profiles, digital batch tracking, and supplier audits. Waste needs handling — aluminum compounds cannot run straight to landfill or water. Here, joint cooperation between supplier and buyer, backed by robust documentation and proactive hazard reviews, sets a strong path for improvement. Science keeps pushing for new synthesis routes, maybe reining in process waste or unlocking better forms (spherical, coated, micronized) for specialized medicines. Policy changes sometimes lag behind, so leading producers frequently consult with regulatory and environmental experts, anticipating not just today’s standards but tomorrow’s hurdles.
Chengguan District, Lanzhou, Gansu, China
