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Calcium Hydrogen Phosphate Dihydrate, described by its formula CaHPO4·2H2O, sees wide use in the pharmaceutical industry where its consistency, purity, and traceability really matter. This white crystalline solid takes several physical forms, such as powder or granules. It flows well and resists caking, which helps during mixing, tablet making, or capsule filling. One batch’s powder feels almost sandy while the pearls or granules carry more heft and visual brightness—traits blending utility with easy visual identification during processing. Laboratory experience points to details like a molecular weight of 172.09 g/mol and a density near 2.32 g/cm³, important for calculating dosages and preparing suspensions or tablet blends. Though the material itself looks mild, workers always need to remember proper handling, as all fine powders demand respect to avoid accidental inhalation or allergic reactions.
The crystal structure of Calcium Hydrogen Phosphate Dihydrate shows a stable arrangement of calcium, phosphate, hydrogen, and water within its lattice. This gives the compound its strength as an excipient—neither greasy nor volatile, and it resists breaking down when held at room temperature or slightly above. The color remains white or off-white, and it carries no strong odor, so it won’t interfere with sensitive ingredients. Its flake-like and sometimes granular texture arises from the way water molecules lock into place in the lattice. Dissolution testing shows Calcium Hydrogen Phosphate Dihydrate stays only mildly soluble in water—around 0.02 g per liter at 25°C — which means it works well as a filler that won’t dissolve too early in the digestive tract.
For BP/EP/USP pharma grade, the standards focus on achieving the most consistent product. Strict testing checks for calcium and phosphate content, loss on drying (which should stay below prescribed limits), and heavy metal presence, which needs to fall within extremely low marks. Regulatory authorities demand record-keeping and traceability for each lot, supported by accreditations like Good Manufacturing Practice (GMP) and third-party audits. Granule size distribution also matters, as uneven particles react badly in tablet presses—causing breaks or uneven coatings. REACH registration and listing under HS Code 28352500 establish legitimacy for international trade, and country-specific documentation like CEPs (Certificates of Suitability) clear the way for pharmaceutical producers worldwide.
In tablet production, this material comes in handy as a diluent or filler because it holds shape under compression and disperses evenly through various active ingredients. Producers appreciate that its density helps achieve the right balance of compactness and disintegration time—helping pills break down quickly in the stomach, not the manufacturing line. Its chemical stability lets producers store it in well-sealed containers at room temperature without fear of degradation or reaction. Typical appearances in production lines range from fine powders for fast dispersion to firm pearls used where dust control tops the list of concerns. Many facilities use high-throughput hoppers and pneumatic conveyors to handle the powder, ensuring that workers suit up with dust masks and gloves for safety.
Calcium Hydrogen Phosphate Dihydrate does not count as a highly hazardous chemical, yet it can cause mild irritation if handled without protective gear. Inhalation of dust or accidental ingestion beyond pharmaceutical dosages can cause discomfort. Hazard statements from global authorities such as the GHS flag it at a low level: it doesn’t ignite easily, explode, or corrode. Attention to material safety data sheets (MSDS) guarantees that bulk storage and transport happens safely, and facility managers institute training so that staff recognize and correct small spills or airborne dusts. Producers also keep the supply chain transparent to avoid adulteration or contamination, since pharmaceutical clients will only buy from documented sources meeting BP, EP, and USP standards.
The typical raw materials feeding into Calcium Hydrogen Phosphate Dihydrate production come from well-audited sources of mineral phosphates and refined calcium salts. These must pass screening for heavy metals or environmental contaminants early in the pipeline, because any slip in quality at the raw material stage risks failures later in sensitive pharmaceutical applications. Modern production keeps an eye on environmental impact too—designing closed-loop systems, capturing waste streams, and recycling water wherever feasible. As regulatory scrutiny rises, suppliers share third-party analysis results, tracking every shipment from mine or quarry through processing to pharma plant. This transparency makes it possible for pharmaceutical companies to justify the origin and safety of every lot used.
Pharmaceutical manufacturers often find their workflow slowed by variable powder consistency or supply interruptions. One remedy comes from partnering with trusted suppliers who publish batch certificates listing all analytical test results and trace impurities down to parts-per-million. Some sites implement on-site re-testing using X-ray fluorescence or loss on drying ovens. Handling practices such as local exhaust ventilation and sealed transfer systems protect both worker safety and product integrity. When regulatory changes surface—say, new restrictions on allowed levels of impurities—close communication through the procurement chain helps move compliant product without production stops. Standardized batch sizes and long-term agreements put a lid on availability issues, letting production teams keep focus on quality rather than firefighting supply gaps.
Chengguan District, Lanzhou, Gansu, China
