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Diethyl Phthalate Vinegar BP EP USP Pharma Grade is a chemical compound used across a range of industries, especially pharmaceuticals. I’ve come across its name often in conversations with quality assurance professionals and chemical engineers. Simple at a glance, this clear and colorless liquid has the molecular formula C12H14O4 and a molecular weight of roughly 222.24 g/mol. The “BP,” “EP,” and “USP” tags show it meets tough quality standards set by British, European, and US Pharmacopeias. This is important for anyone looking to use safe and compliant raw materials.
In my experience, nothing beats certainty about what’s in the drum or bottle. Diethyl phthalate has a density around 1.12 g/cm³ at 20°C. It’s stable under normal conditions, dissolves easily in alcohol, ether, and acetone, and remains almost insoluble in water. Visually, the material runs from an oily liquid to a faintly sweet aromatic scent. Boiling point sits near 298°C, and it pours out easily, so I never worry about handling it like solid flakes or powders, which can be a pain to dissolve or measure. The chemical sits under HS Code 29173920, so importing and exporting gets a little easier—at least from a paperwork angle.
The structure of this compound consists of two ethyl groups attached to phthalate acid at the oxygen spots on the benzene ring. That may seem irrelevant unless you’re deep into the world of organic chemistry. Maybe you’re working in a lab like I was several years back, watching for reactivity and stability in formulations. Diethyl phthalate remains relatively low on the hazard scale. Still, that doesn’t excuse sloppy handling. The material can irritate the skin or eyes, and if you work around it without good ventilation, headaches and dizziness show up in short order. Keeping spill clean-up kits on hand just makes sense. Wash up right after, don’t eat or drink in the work area, and always keep your eyes up for new info on toxicity and handling—the European Chemicals Agency and OSHA update guidelines all the time, and it pays to be ready.
Mostly, diethyl phthalate turns up as a liquid. In the years I’ve seen it in inventory, I haven’t spotted it as flakes, pearls, or a solid powder form. This keeps things predictable for batch mixing and formulation work. It’s this form that lets pharmaceutical manufacturers add it as a solvent or fixative without much fuss. But it’s not unheard of for specialty orders to arrive in crystal or solid forms, depending on custom requirements or local distribution practices—though liquid still dominates. If you work in a smaller lab, handling large liquid containers brings its own challenges. Always check for container integrity, accurate labeling, and secure transportation because overlooked spills in a storeroom can create unsafe slip hazards and potential for skin exposure.
One thing I’ve learned working alongside purchasing leads is that the trail backs up fast, all the way to crude oil. Diethyl phthalate starts as phthalic anhydride reacted with ethanol or ethyl alcohol in the presence of an acid catalyst. This background matters because impurity levels and trace contaminants hinge on these starting materials and the care involved in the process. Right now, the sourcing debate runs hot—the public wants fewer petrochemicals in the supply chain, and regulators add more hoops each year. Manufacturers tighten specifications and run more checks for any trace hazardous substances such as residual methanol, heavy metals, or other byproducts that could cause trouble later.
Ask anyone who’s worked between a research bench and a production floor, and they’ll tell you—diethyl phthalate isn’t the most dangerous material, but that doesn’t mean it’s harmless. Health agencies have flagged it for possible links to hormone disruption at high doses, especially with chronic exposure. Personal safety often comes down to routine: gloves, goggles, lab coats, and a good sense for avoiding careless mistakes. Strong labeling, segregated storage, and up-to-date hazard communication sheets make a difference—especially where staff turnover means new handlers regularly step in.
Continued use of diethyl phthalate keeps driving questions from both environmental and occupational health standpoints. Some countries push for alternatives, others ban certain uses, yet demand for consistent, high-quality raw materials lingers in pharmaceutical, cosmetic, and personal care sectors. One answer points to stronger internal controls—traceability, supplier auditing, batch testing. Regularly updated process safety training means fewer accidents over time and less risk of regulatory blowback. Where it’s possible to swap to less hazardous plasticizers, some companies do, though true drop-in replacements aren’t always easy to find. Talking through these challenges with procurement teams makes a real impact because buying higher-purity or certified materials typically costs more but saves downstream headaches.
Specifications listed on a certificate of analysis go past bureaucratic formality. Results for appearance, assay, acidity, water content, specific gravity, and any related substances show up in batch records for years. Auditors want to see not just that a facility meets BP, EP, or USP standards, but also that it tracks how specifications are set, how batches are released, and how potential out-of-spec results are handled. Missteps in this area affect product recalls, regulatory fines, and—most serious—patient safety. Using only products that match pharma grade purity isn’t just about regulatory box-ticking, it speaks to real trust between manufacturers, patients, and regulatory agencies. As regulations shift toward more transparency, better safety, and full accountability, the companies that keep thorough, honest paper trails fare better and support safer pharmaceutical outcomes.
Chengguan District, Lanzhou, Gansu, China
