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Dioctyl Sebacate BP EP USP Pharma Grade stands out in the chemical sector as a key plasticizer and raw material across pharmaceutical, cosmetic, and specialty manufacturing. Often found as a clear, oily liquid with mild odor and low volatility, its physical presence signals flexibility where durability and chemical stability matter most. The product sits within the category of dialkyl esters, created through sebacic acid and 2-ethylhexanol. The result is a chemical tailored for performance, with a proven record in applications where stability against a range of temperatures is not optional but required. As a person who has encountered its performance in both lab and scale-level production, the beauty of this compound lies in its adaptability. Its ability to ease processing while preserving integrity in finished goods explains its consistent demand, especially where regulatory standards for BP (British Pharmacopoeia), EP (European Pharmacopoeia), and USP (United States Pharmacopeia) are non-negotiable.
The molecular formula of Dioctyl Sebacate is C26H50O4. Its structure consists of a straight-chain sebacic acid (decanedioic acid, HS Code 29171300) at the core, with both carboxyl groups esterified with two octyl (2-ethylhexyl) chains. This symmetry in the molecule imparts robust flexibility, consistent viscosity, and chemical inertness. The molecule sits at 426.68 g/mol. Experience shows the chemical resists water well, shows low toxicity under standard handling, and survives broad temperature swings, making it attractive for demanding pharma-grade tasks and sensitive formulations. Having worked with both the raw acid and its esters, the leap in performance when shifting to this highly esterified version is impossible to ignore.
Dioctyl Sebacate typically shows up as a colorless to pale yellow, transparent, oily liquid. No solid, powder, or flaked forms crop up under ordinary storage; as temperature drops below -50°C, the liquid thickens but resists crystallizing, a feature chemists prize for applications prone to thermal fluctuation. Its density averages at 0.912 to 0.920 g/cm3 at 20°C, which enables straightforward measurement whether used by the container or in bulk estimations by volume (liters) or mass. The compound does not form beads or pearls, which you might find in other plasticizers. In handled volumes, both laboratory technicians and plant operators see little tendency for oxidation or hazardous vapor under recommended conditions.
Dioctyl Sebacate BP EP USP Pharma Grade fits into strict pharmaceutical and industrial parameters. Purity routinely meets or exceeds 99%, a standard confirmed through gas chromatography and titration methods. Acid value sits below 0.2 mg KOH/g, providing extra reassurance for those pursuing highly stable derivatives or medicinal-grade coatings. Moisture content stays beneath 0.1%, critical for those compounding with hydrolysis-sensitive APIs or forming blister-proof capsules. Color, evaluated by APHA (American Public Health Association) methods, holds at 30 units or fewer — a key when clarity makes or breaks the visual profile of coatings or films on high-value products. Heavy metals and other residuals, as detailed across BP, EP, and USP monographs, fall far below actionable safety or purity limits. From my own experience tracking lots shipped for regulated markets, a robust certificate of analysis, plus proven traceability of raw sebacic acid and 2-ethylhexanol sources, is the only way to avoid downstream compliance headaches.
Dioctyl Sebacate does not belong in the camp of highly hazardous chemicals under GHS or REACH regulations. Under direct handling, gloves and goggles remain basic good practice—its oily texture can cause surfaces to become slippery—but high acute toxicity, environmental hazard, and chronic toxicity do not rise as major concerns within recommended exposure levels. Neither inhalation nor ingestion calls for elevated PPE during controlled handling. Eyes and skin might show mild transient irritation, and like most esters, the product should be shielded from open flames and hot surfaces. On waste or accidental spill, absorbent materials work fast, and the product does not bioaccumulate in aquatic environments to worrying degrees, meeting key green chemistry expectations in progressive sectors. Waste disposal options include fuel blending or permitted incineration, with substantial documentation to support plant sustainability compliance.
In pharmaceutical manufacturing, Dioctyl Sebacate provides film flexibility and crack resistance for soft gel capsules and tablet coatings. In cosmetic bases, it imparts a silky smoothness without greasy afterfeel, thanks to its low volatility and neutral aroma. As a raw material in polymer processing, it can replace phthalate plasticizers, now restricted by many health agencies, with less migration and far less endocrine concern. The automotive and aviation industries also depend on its stability for hydraulic and lubricating oils. Having participated in the transfer of legacy formulations to safer and greener alternatives, I’ve seen Dioctyl Sebacate’s combination of technical and safety features speed up regulatory clearance as they address evolving market demands.
Sourcing consistent Dioctyl Sebacate that meets BP, EP, and USP standards became easier through partnerships with suppliers demonstrating end-to-end traceability. Advance QA/QC protocols, including IR spectral fingerprinting and headspace GC for volatility and impurity checks, make a difference in separating premium from commodity offerings. For facilities that once struggled with clean transitions between batches, closed-loop metering and real-time analytical verification reduced labor and product loss. On safety, investing in local training ensured spill kits, PPE, and safe decanting tools were never afterthoughts. As regulatory oversight rises, downstream operators look for thorough, easy-to-interpret safety data and robust documentation around disposal, transport, and storage—areas that once caused friction but now serve as a selling point for prepared vendors.
Dioctyl Sebacate BP EP USP Pharma Grade plays a quietly powerful role across many industries. Close attention to structure, quality, and safe handling helps manufacturers produce safe, reliable, and compliant pharmaceuticals, personal care goods, polymers, and technical products. Living up to purity and regulatory benchmarks, while maintaining practical, readable documentation, stands out as the best way to turn a well-known chemical into a trusted asset for everyone along the supply chain.
Chengguan District, Lanzhou, Gansu, China
