Dipotassium Hydrogen Phosphate, often called potassium phosphate dibasic, comes from combining potassium and phosphate in a precise chemical relation. It fits into formulas across industries, especially pharmaceuticals, food, and lab applications, due to its well-known properties. Chemically, it holds the formula K2HPO4 and brings together potassium ions and hydrogen phosphate ions in a white, crystalline appearance. Many see it in solid form, but solutions and powders also have their place depending on the project or process. This compound offers stability in both structure and function, making it a dependable backbone for buffer solutions, nutritional supplements, and chemical synthesis work. Rather than seeing a catch-all chemical, users find clear, defined benefits that trace back to its molecular setup and physical reliability.
Dipotassium Hydrogen Phosphate BP EP USP Pharma Grade takes on several forms — flakes, granular powder, pearls, solid, and crystal. As a non-volatile, odorless substance, its appearance as a white powder or crystals tells you something about its purity and refinement. The molecular formula sits clearly as K2HPO4, with a molecular weight of 174.18 g/mol. Potassium content stands high, which adds value when precise mineral sourcing is required, like in buffer formulations or electrolyte solutions. The property of high solubility in water sets it apart; from my experience in the lab, few substances dissolve as predictably, giving a clear, stable phosphate buffer that holds its pH without wild swings. The density generally measures around 2.44 g/cm3 for the solid product. Finer powders pass easily through a standard mesh, making blending into liquid or solid matrices straightforward, whether adjusting pH in pharmaceutical manufacturing or balancing nutrients for hydrated foods. In specific applications, you see it in concentrations like 1M or 0.5M solutions, each delivering the same core identity — reliable, consistent behavior thanks to a tightly held chemical structure.
Under scanning or even the naked eye, Dipotassium Hydrogen Phosphate stands as a visual symbol of purity; white hygroscopic crystals or free-flowing flakes fill containers evenly, with no signs of discoloration, no caking if stored properly. From raw material storage bins in pharmaceutical plants to glass jars in my own chemistry workspace, it holds up against moisture and air far better than some other potassium salts, although high humidity can draw in water to form a hydrate. The crystalline structure shows regularity at the microscopic level, borrowing from its molecular arrangement. Handling this raw material means scooping or weighing a dust-free, low-static powder that pours evenly into reaction vessels. In the scale of global trade, producers package it according to strict regulatory demands and coding, stamped clearly with the HS Code 28352400 for potassium phosphates.
Dipotassium Hydrogen Phosphate supplied as BP EP USP Pharma Grade guarantees high purity; potassium and phosphate levels match pharmacopeial standards, and heavy metals must rest well below accepted thresholds. Contaminant monitoring remains sharp — iron, arsenic, lead, and other toxins are strictly capped, with testing performed by independent and internal analysts. For pharmaceutical use, a loss on drying maximum of 1% often applies, keeping water of hydration controlled to prevent batch inconsistencies. Each batch comes with a Certificate of Analysis outling potassium content, pH of a standard solution (usually 9.0 to 9.6 for a 1% aqueous solution), and clarity of solution. Sometimes I’ve seen discussions about fine-tuning mesh size for tableting behavior; the compound responds well to this customization, holding its tap density and flow rate in blending and tableting machines, provided humidity is low. Raw materials undergo further visual inspection for clumping, dust, or foreign bodies so that production lines stay contaminant-free and FDA-compliant.
Dipotassium Hydrogen Phosphate rates as a chemical often labeled non-hazardous by major safety codes, but care doesn’t go amiss. In my own handling, gloves and goggles limit eye and skin irritation, especially for operators exposed to kilos of raw material at a time. None of the classic red flags of toxicity or personal danger hover over this product, so long as good laboratory or plant hygiene holds. Accidental exposure rarely brings lasting harm; dust can cause mild mechanical eye or respiratory irritation. Long-term handling hasn’t shown toxic effects in the literature, but like with any inorganic salt, chronic exposure to large quantities should get flagged and scheduled against. The chemical scores low for hazardous transport — it isn’t flammable, explosive, or self-reactive under normal conditions. Clean-up stays simple: industrial vacuum or mop clears up dry spills, and water rinses dissolve residues easily. Material Safety Data Sheets, from my perspective, exist not because of acute danger, but because regulatory authorities demand clarity and real safety culture.
Demand for Dipotassium Hydrogen Phosphate in pharma and nutrition stands on strong foundation. Nutritional supplements and intravenous fluids rely on this raw material to meet potassium and phosphate needs for human health. Buffer solutions in biological or diagnostic labs depend on its ability to keep solutions at just the right pH, not just in theory but in batch after batch. Medicine production picks this chemical for buffering antibiotic syrups, eye preparations, and injectable fluids. Food industries stretch their use to emulsifying salts in cheese or as a mineral fortifier in processed foods and beverages. Personal experience taught me the ease with which a clear, pH-controlled solution forms, supporting enzymes in diagnostic kits or advancing chromatography methodologies. The right grade — BP, EP, or USP — lines up with each regulatory regime, a fact not lost on procurement teams working to keep audits smooth and products consistently high-grade.
Across the globe, Dipotassium Hydrogen Phosphate moves under the HS Code 28352400, and each market imposes its own standard for pharmaceutical grade quality. Regulatory compliance means every supply chain needs robust documentation — traceability, batch tracking, and Certificates of Analysis for every shipment. Many countries require proof of adherence not just to BP, EP, or USP, but sometimes a blend of the three, putting pressure on suppliers and manufacturers. Sourcing this raw material calls for careful relationships with trusted vendors, as fluctuations in supply or purity can throw off manufacturing schedules or regulatory filings. Quality assurance teams scrutinize every shipment for purity, moisture content, and compliance with pharmacopeial references. From hands-on experience, working with certified vendors gives peace of mind — out-of-spec batches threaten not only end product quality but patient safety as well. Sophisticated logistics and temperature-controlled storage solutions round out the distribution package, especially when material goes direct into sterile or high-purity pharmaceutical processes.
Dipotassium Hydrogen Phosphate BP EP USP Pharma Grade draws its value from its unshakable consistency, sharp specifications, and global acceptance as a pharma and nutrition raw material. The challenge isn’t just meeting specification on a lab sheet, but doing it day after day, across container loads, while maintaining safety, traceability, and a transparent supply chain. In the push for sustainable sourcing and circular chemical production, attention shifts to greener synthesis routes, tighter contaminant monitoring, and smarter distribution. As more sectors demand cleaner, safer, and better-documented chemicals, the role of Dipotassium Hydrogen Phosphate sits at the intersection of regulatory vigilance and practical, everyday reliability — a material linked to quality outcomes in everything from buffer prep to advanced pharma work.