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People in the pharmaceutical world know Hypromellose 2910 as a mouthful of a name for a steady, reliable pharmaceutical excipient that plays a quiet but central role in everyday formulations. The roots stretch back to cellulose, a natural plant-derived polymer, tweaked and tailored through chemical synthesis to create a sturdy blend of methyl and hydroxypropyl groups. What stands out with the 2910 type is a specific ratio between methoxy and hydroxypropoxy groups, making a difference for anyone working with tablets, capsules, or gel-forming materials. The BP, EP, and USP parts indicate compliance with British, European, and United States Pharmacopoeias, keeping things in line with strict international safety and quality benchmarks demanded by medicine manufacturers and regulators.
In everyday handling, Hypromellose 2910 presents as a white to off-white odorless powder, with the ability to take the form of granules or flakes, echoing the variability across manufacturing facilities and supply chains. Touching the material reminds anyone seasoned in excipients about its signature smoothness and compressibility, whether scooping into a weighing boat or dusting down a blending tank. It remains stable under normal conditions, not given to volatile or hazardous breakdowns, which is a considerable relief during warehouse storage and transport. The density floats around 1.25 g/cm³, and it does not dissolve in cold water outright but swells to form a gel, showing its value in extended-release dosage forms—a key to controlling drug delivery over hours instead of minutes. In hot water, it dissolves, then forms viscous solutions cooling down, marking its role as a binder, film-former, and thickener.
Chemically, its backbone comes from cellulose, where some hydroxyl groups are substituted with methoxy and hydroxypropoxy groups. Its empirical formula reflects this as C18H38O14, but in the real world, the structure varies—copolymers always come with a distribution of chemical groups, so in practice you work with an average, not a tidy molecule. The long chains drive film formation and gelation, critical for anyone interested in drug release properties. The substance remains chemically inert with most actives and excipients, allowing scientists to think more about formulation than about unwanted reactions.
Pharmacopoeial standards require tight tolerances over viscosity, loss on drying, substitution degree, and purity. The USP, BP, and EP monographs enforce good manufacturing practice, pushing for batch reporting of particle size, viscosity (typically 3–120,000 mPa·s measured in 2% aqueous solution at 20 °C), and clarity in water, helping reduce batch-to-batch variation. As a pharmaceutical raw material, regulators and customs classify Hypromellose 2910 under HS Code 3912.90, lumping it in with cellulose ethers, so everyone from importers to customs authorities speaks the same language. That clarity saves headaches at borders and ensures that certificates of analysis and safety data sheets match up across continents.
Commercially, suppliers ship Hypromellose 2910 usually as a powder, flakes, or granules, most often in high-thickness, food-grade polyethylene-lined fiber drums. Good packaging preserves the low moisture content, stopping caking or out-of-spec gelation. Every formulation scientist or plant technician knows the value of consistent handling here—fine dust from the powder form irritates airways if mismanaged, so automated feeding systems, dust extraction, and regular PPE checks matter each working day. In solution, Hypromellose forms a clear or hazy viscous gel, essential for coating solutions, as well as eye drops and oral suspensions. Each form comes with a different pourability and solubility profile; those working on large-scale tablets or specialty delivery forms tend to gravitate toward the format that saves time and money through easier dispersion and mixing.
Pharma grade Hypromellose plays a practical role in almost every solid oral formulation line. Tablet binders, film coatings, and controlled-release matrices rely on this ingredient for robustness and reproducibility. Anyone who's pressed tablets knows that properties like compressibility and binding save on API loss, reduce tablet defects, and keep machines running smoothly. In eye drops, the material’s high viscosity brings long retention time on the eye, improving efficacy for conditions like dry eye and conjunctivitis, while ensuring minimal irritation or reactivity for sensitive tissues.
Unlike some raw materials that require hazmat gear, Hypromellose 2910 classifies as low hazard under most regulatory regimes. It triggers minimal toxicity through oral or dermal routes; for occupational safety, the main risk is airborne dust, which reminds plant operators to avoid long exposures and keep dust control measures in check. Safety Data Sheets usually recommend gloves and dust masks, and any spills clean up with sweeping or vacuuming. Environmentally, the biodegradable cellulose backbone breaks down in soil and water, avoiding the kind of accumulation and toxicity seen with non-degradable synthetic polymers. Disposal, where regulated, rarely brings pushback from authorities, given the material’s low environmental burden and established safety profile.
Manufacturers who work with Hypromellose 2910 need to keep one eye on moisture content and another on particle size. Even moderate increases in water absorption during storage mess with viscosity and performance. Packaging lined with humidity barriers, regular checks on drum integrity, and careful rotation of stock all help to maintain consistency on scale-up, as I’ve seen first-hand in plant operations. During formulation, plenty of mixing energy and a gradual hydration step stop crumping and undissolved lumps, reducing process losses for those scaling from bench to pilot to full production. Supplier audits, lot verification, and annual regulatory reviews all form the background to sustaining quality and compliance—nobody wants a batch kicked back due to out-of-spec viscosity or missing documentation in today’s regulatory-focused landscape.
Hypromellose 2910 BP EP USP Pharma Grade stands as a versatile, dependable raw material in the pharma industry. Its unique blend of physical and chemical properties, regulatory compliance, and broad application ensure its continued importance as both an ingredient and a material underpinning the safety and efficacy of medicines globally. Solid handling practices, ongoing supplier assessment, and careful quality checks remain central to maximizing its value in daily use.
Chengguan District, Lanzhou, Gansu, China
