Contact Us
Chengguan District, Lanzhou, Gansu, China
© 2025 Jeifer Pharmaceutical, All Right
Reserved.
L-Menthyl Glyoxylate Hydrate BP EP USP Pharma Grade is a raw material used in pharmaceutical and fine chemical manufacturing, standing out for its distinct set of physical and chemical properties. This substance emerges from a blend between menthyl, the primary component of natural menthol, and glyoxylate, forming a hydrate that displays a definite crystalline character under most storage conditions. Its molecular formula typically reads C12H20O4·H2O, supporting a molecular weight that rests near 246.3 g/mol, a figure that carries genuine consequences when calculating precise batch yields or designing downstream processing. In various forms, whether as flakes, powder, pearl-sized segments, or fine crystals, its solid phase showcases a white to off-white shade. Rarely does it present as a liquid under standard ambient conditions unless subjected to significant temperature shifts; once dissolved or suspended, it brings a clarity appropriate for solution-driven applications.
In practical lab experience, the density serves as a real differentiator, sitting at roughly 1.15 g/cm³, which provides clear hints for mixing, handling, and storage. Its melting range remains narrowly fixed in the mid-50°C zone, signaling reliable use where thermal stability is essential. The hydrated structure means this material maintains a certain resilience against short-term desiccation yet does not tolerate high humidity or exposure to direct sunlight over time. The compound is soluble in common polar solvents like ethanol or methanol, while insolubility in nonpolar media makes it a selection point for targeted pharma formulations. It rarely emits strong odors, another bonus for workspace comfort and product handling in confined spaces. An HS Code of 29145000 commonly classifies this chemical, falling among organic acids and their derivatives, signaling its regulatory and customs designation for global distribution.
Structurally, the glyoxylate moiety’s aldehydic function stays chemically reactive—a fact I have encountered during various synthetic transformations, especially during coupling or reductive amination procedures. The menthyl portion contributes unique stereochemistry, imparting not only a subtle organoleptic profile but also governing how the molecule interacts with living biological systems. Together, these elements deliver both chiral purity and a clean reactivity profile, valued by formulators striving for tight control over product consistency. Manufacturers often look for tight compliance with British Pharmacopoeia (BP), European Pharmacopoeia (EP), and United States Pharmacopeia (USP) standards, reflecting strict requirements for purity, water content (bound as hydrate, generally around 4-6%), and minimal permissible levels for heavy metals or residual solvents.
Depending on the final use, L-Menthyl Glyoxylate Hydrate can arrive in various material forms. Many chemical warehouses stock it as flakes, which reduces dusting during handling and pouring—critical for safety and waste reduction. Other labs prefer the product in a finely milled powder or in compact, pearl-like lumps, which allows precise weighing and mixing. Large-scale users might request the substance in ready-to-dissolve crystalline bulk or pre-mixed solution for ease of manufacturing. Unlike bulk chemicals that come in jumbled batches, this material’s pharma grade guarantees traceability at every step, which supports process audits and regulatory reviews.
Direct contact with L-Menthyl Glyoxylate Hydrate can irritate the skin and eyes, making personal protective equipment (PPE) like gloves and goggles a baseline requirement on the warehouse floor or in the laboratory. Inhalation of dust from powder or flakes can trigger respiratory discomfort, especially over prolonged exposure. Proper ventilation and dust extraction systems create safer air quality. The material’s chemical reactivity also signals caution around strong oxidizers and reducing agents; inadvertent mixing in waste containers has led, in documented cases, to unwanted side reactions. Because the hydrate binds water, exposure to high heat or overly arid storage accelerates dehydration, changing both its weight and handling properties. Manufacturers need to keep it in tightly-sealed, labeled containers—polyethylene or glass for best stability. Storage in cool, shaded areas prevents degradation and accidental liquefaction or clumping. Fire safety data rates the compound as presenting low flammability under standard protocol, but once heated to decomposition, it releases acrid fumes that include oxides of carbon.
Use cases show up most often in pharmaceutical synthesis, where L-Menthyl Glyoxylate Hydrate acts as a building block for chiral intermediates and active pharmaceutical ingredients (APIs). In those settings, even trace impurity levels can shut down a production batch or trigger regulatory investigations. Its presence in BP, EP, and USP monographs marks the need for verified sourcing channels and fully traceable supply lines. For market entry into the European Union or North America, all shipments submit to HS Code classification, customs scrutiny, and required safety data sheet (SDS) submission. Producers must keep certificates of analysis (COA) for each lot, confirming both specification compliance and absence of prohibited contaminants. The raw material’s tight parameters underline its position in GMP (Good Manufacturing Practice) pipelines; unrecognized sources, substitution, or mislabeling can result in not just costly recalls, but also legal liability.
Accidents involving L-Menthyl Glyoxylate Hydrate often boil down to oversight—incorrect stacking of bags, neglecting moisture control, or omitting PPE. Training all staff on hazard pictograms, SDS details, and emergency spill procedures makes a real difference. Eyewash stations and spill kits belong close to storage areas, not down the hall or in adjacent labs. Waste disposal has to follow local hazardous material protocols; this hydrate does not belong in regular landfill or untreated drainflows. Controlled incineration or chemical neutralization under supervision remains the soundest solution for large-scale disposal. In manufacturing, in-line sensors can monitor powder dust levels, while electronic batch records give real-time traceability in the event of a product recall or quality dispute.
Market demand for L-Menthyl Glyoxylate Hydrate has risen with the growth in enantioselective chemical synthesis, and the stress this places on supply chains shows up in cost spikes and occasional batch delays. Partnering with reputable, certified producers and requesting full transparency on raw material origins can soften the blow of shortfalls. Sustainability also means responsible stewardship—producers that invest in clean synthesis (green chemistry protocols, closed-loop water recycling) actually help safeguard long-term access; this knocks down both waste and negative environmental impact, which has changed the way many buyers shortlist suppliers today. Frequent site audits, robust supplier agreements, and routine lab analysis secure ongoing compliance, keeping pharma-grade batches clear of avoidable mishaps.
Chengguan District, Lanzhou, Gansu, China
