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Polyethylene Glycol Monooleate Glycerol Ester BP EP USP Pharma Grade stands out as a multifaceted non-ionic surfactant, shaped by the reaction of polyethylene glycol, monooleic acid, and glycerol. Used across the pharmaceutical industry, this compound steps up for its emulsification, solubilization, and stabilizing properties, making it more than just another ingredient in the lab or on the production floor. You’ll find it as a common component in creams, ointments, suspensions, and injectable formulations. Its versatility does not stop at just the lab bench; its safe record for human use is traceable through every pharmacopoeial reference it meets. For anyone working near pharma formulations, the presence of this material usually signals efforts toward improving drug delivery, texture, and consistency.
The molecular formula for this ester takes the shape of C18H34O2(C2H4O)n, where n reflects the average number of ethylene oxide units, usually between 15 and 40 depending on the intended grade. Chemically, you get a monoester of oleic acid and glycerol, further linked to polyethylene glycol by ether bonds. This branching structure enables both hydrophilic and lipophilic behavior—meaning the molecule blends well with oils and water. With variations in physical appearance, the product shows up as a pale yellow translucent liquid, soft waxy solid, or sometimes as powder, flakes, or even pearl-like granules. Temperature and grade control make a significant difference: less polymerization gives you liquids, higher leads to semi-solids or powders.
The density of this compound often slips right between 1.05 g/cm3 and 1.12 g/cm3 at room temperature, with a melting point for solid grades around 25°C to 35°C. As a raw material, it draws attention for its solubility profile—soluble in water, ethanol, chloroform, and many vegetable oils. The water solubility ensures rapid dispersion, which matters a lot for both oral and injectable pharmaceuticals. Here’s where years in the field offer perspective: stability during autoclaving and pH resilience means fewer headaches for formulation scientists, giving shelf stability and product integrity over time.
Polyethylene Glycol Monooleate Glycerol Ester steps up in compounded creams, acting as an emulsifier and solubilizer for tricky actives and excipients. It helps drugs mix smoothly and improves absorption through skin or mucosal membranes. Hospitals and compounding pharmacies count on this function for uniform dose delivery and patient comfort. Injectable formulations rely on its compatibility and low toxicity. Stability against hydrolysis makes it a better choice over some traditional surfactants, reducing batch failures. No matter if the formula runs as a solution, cream, gel, or injectable, this ingredient brings both consistency and trusted safety records in patient-administered drugs.
As someone who has dealt with raw chemical materials, safety data matters. According to global safety standards, including the European Pharmacopoeia and United States Pharmacopoeia, this surfactant classifies as low hazard. The acute toxicity profile remains mild, even with oral or dermal exposure at pharmaceutical doses. Chronic exposure data shows no significant carcinogenic or mutagenic risks, according to regulatory dossiers. Handling as a raw material should follow standard chemical safety measures: gloves, goggles, and good ventilation, particularly during large-scale batch processing to avoid direct skin contact with concentrated forms. It goes by HS Code 34021300 in most customs documentation—worth noting for shipping, import, and export compliance.
Users commonly encounter Polyethylene Glycol Monooleate Glycerol Ester as pale yellow viscous liquid, soft wax, powder, crystal chunks, or in pearl shapes, adjusted by cooling rates and the degree of ethoxylation. For lab work, liquid and soft forms ease weighing and dosing. Powder or flakes work better for solid formulations. Storage in airtight containers under cool, dry conditions preserves quality. Some manufacturers ship in HDPE drums, plastic pails, or sachets, always meeting the required pharma-grade compliance for raw material handling. Whatever the form, the essential properties stay the same: stable molecular integrity, reliable density, and quality fit for medical use.
While the acute toxicity looks minimal in practice, questions about environment and sustainability never stray too far from the table. The manufacturing route draws from petrochemical sources, with polyethoxylation processes resulting in some environmental load. Disposal involves standard chemical waste management rather than dumping in regular sewer or landfill—preventing contamination of groundwater and reducing ecosystem impact. Innovations in green chemistry, particularly using plant-derived oleic acid or shifting toward biodegradable variants, make a genuine difference. To push sustainability further, switching production lines to cleaner, renewable-powered facilities offers a path forward, not just for this compound but for pharma chemistry at large.
Polyethylene Glycol Monooleate Glycerol Ester BP EP USP Pharma Grade anchors itself as a trusted solution for formulators and manufacturers, drawing on its strong safety profile, physical versatility, and compatibility with active pharmaceutical ingredients. Its presence in pharmaceuticals has grown through its proven record, adaptability across dosage forms, and adherence to strict pharmacopoeial quality standards. Continuous innovation in sourcing and greener production will strengthen its role, balancing high performance with sustainability and safety for both patient and planet.
Chengguan District, Lanzhou, Gansu, China
