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Sodium Bicarbonate for Injection BP EP USP Pharma Grade stands as a highly refined chemical compound, purpose-built for medical and pharmaceutical uses. This grade adheres to international pharmacopeias, including British Pharmacopoeia (BP), European Pharmacopoeia (EP), and United States Pharmacopeia (USP). Its precise composition and rigorous production mean the compound meets standards required for intravenous or direct patient use. The molecular formula NaHCO3 marks the central structure: a simple, crystalline solid made up of sodium, hydrogen, carbon, and oxygen. Medical practitioners depend on sodium bicarbonate solutions to correct acid-base imbalances, support resuscitation, and manage metabolic acidosis, underscoring just how essential purity and specification prove.
Sodium bicarbonate appears in several forms suited for batch preparation and transport. Its solid state is most often a fine white powder, free from clumping or foreign odor. The material stays stable under standard conditions, resisting decomposition unless exposed to strong heat or acidic solution. Crystal forms may emerge as small flakes, pearls, or uniform granules. Its molecular weight measures at 84.01 g/mol. Sodium bicarbonate remains highly soluble in water, with a tendency to increase solution pH as it interacts. Pharmaceutical suppliers ship both solid and solution forms, with labs preparing injectable concentrations measured by volume (such as 8.4% w/v solutions in liter or milliliter volume for intravenous administration). The solution typically achieves a clear, colorless appearance, signaling the absence of contaminants. Density for the solid ranges around 2.2 g/cm3, a figure critical in precise mixing or batch calculations.
The substance’s crystalline structure contributes to its easy dissolution and uniform dispersion in pharmaceutical solutions. Rigorous quality control during manufacturing ensures batches maintain low levels of insoluble residues, heavy metals, and microbial load. Certificates of analysis list parameters such as pH, clarity, solubility, assay (percent of actual sodium bicarbonate by weight), and absence of pyrogens or endotoxins. Particle size gets monitored closely, since consistent dimensions help avoid settling or incomplete mixing. Typical purity exceeds 99.5%. This level of precision matters because trace impurities or inconsistent structure can trigger reactions or lower treatment reliability. Product labels specify batch number, expiry date, packaging type, and volume or weight per container for strict traceability.
Pharmaceutical-grade sodium bicarbonate serves vital clinical purposes, trusted by emergency medicine, intensive care, and pharmacy services worldwide. Injections of this compound buffer excess acid in the bloodstream, offering fast correction in cases like cardiac arrest or diabetic ketoacidosis. Its rapid action saves lives when the body’s pH spirals out of balance. The safety profile, combined with precise chemistry, builds confidence in hospital responses and outpatient therapy formulas. Healthcare teams trained on sodium bicarbonate’s pharmacokinetics can fine-tune dosage based on lab results, patient age, and clinical urgency. Pre-filled vials, ampoules, and bulk containers remain sterile until use, preventing infection and dosing errors. In my experience supporting pharmacy workflows, strict attention goes into storage, shelf life, and handling. Mismanaging concentration or storage can cause dosing miscalculations, which reinforces why pharma-grade distinction and training matter so much.
Shipping, handling, and administering sodium bicarbonate for injection follow clear safety guidelines. Pure sodium bicarbonate carries minimal toxicity yet demands respect due to the high concentrations used for injection. Direct exposure to eyes, prolonged skin contact, or inhalation should be avoided in raw state. Spills on surfaces require cleanup protocols that prevent accidental dust inhalation. Material Safety Data Sheets warn first responders about possible harmful reactions if mixed with acids or strong oxidizers—large releases may cause local alkalinity changes in water systems, which is why disposal routines match healthcare and environmental rules. Emergency kits list sodium bicarbonate as a low-hazard substance for handlers when all protocols get followed, but overdose by injection can lead to serious metabolic complications, hypernatremia, or tissue irritation. In clinical settings, barcoding, patient labeling, and infusion pump programming keep administration on track. Guidelines also call for protective gloves, masks, and eyewear in pharmaceutical plants and hospitals. In years spent consulting on laboratory stock control, I learned that close inventory management and real-time tracking stop untrained hands from accessing raw sodium bicarbonate, reducing risk.
Manufacturers derive sodium bicarbonate by reacting purified sodium carbonate with carbon dioxide and water, yielding the white crystalline product after filtration and washing. Only select raw materials enter the production stream, as contamination at this phase threatens the batch's medical safety. Quality assurance audits inspect supply lines for consistency and compliance with regulatory and pharmacopeial requirements. The finished product for injection ships under classification 283630 for the Harmonized System (HS) Code, marking its status as a chemical and medicinal product for international trade and customs. Technical staff track every shipment by batch and HS code for transparency and regulatory reporting. The infrastructure built around sodium bicarbonate not only delivers essential injectable medicine—it keeps health systems ready for emergencies, persistent chronic care, and acute therapy.
Chengguan District, Lanzhou, Gansu, China
